OTUD7B and MINDY1

Data Source:
BioGRID (genetic interference)

		OTUD7B	MINDY1
Description		OTU deubiquitinase 7B	MINDY lysine 48 deubiquitinase 1
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Nucleoplasm Cytosol Nuclear Body Cell Periphery
	Molecular Function	DNA Binding Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Cysteine-type Peptidase Activity Zinc Ion Binding K63-linked Polyubiquitin Modification-dependent Protein Binding Lys48-specific Deubiquitinase Activity	Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Cysteine-type Carboxypeptidase Activity K48-linked Polyubiquitin Modification-dependent Protein Binding Lys48-specific Deubiquitinase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Adaptive Immune Response Mucosal Immune Response Protein Deubiquitination Protein Phosphopantetheinylation Negative Regulation Of Interleukin-8 Production Protein K11-linked Deubiquitination Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Protein Deubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Protein Localization To Nucleus	Biological_process Protein Phosphopantetheinylation Protein K48-linked Deubiquitination
Pathways		TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway Ovarian tumor domain proteases
Drugs
Diseases
GWAS		anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Bipolar disorder ( 31043756) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Breast cancer ( 29059683) Heel bone mineral density ( 30598549) Height ( 25282103) Obesity-related traits ( 23251661) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656) Triglyceride levels ( 32154731)
Interacting Genes		18 interacting genes: AURKA CCNB1 CDC20 CDIP1 DAZAP2 EPM2AIP1 FZR1 HSFY1 HSFY2 OTULIN PPP1R32 PSMB1 SOX2 SPART TRAF6 UBC UBE2S ZDHHC17	4 interacting genes: DAZAP2 GMCL1 LSM8 UBC
Entrez ID		56957	55793
HPRD ID		10313	07746
Ensembl ID		ENSG00000264522	ENSG00000143409
Uniprot IDs		Q6GQQ9	D3DV11 Q8N5J2
PDB IDs		5LRU 5LRV 5LRW	5JKN 5JQS 5MN9
Enriched GO Terms of Interacting Partners?
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