IMPDH1 and IMPDH2

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		IMPDH1	IMPDH2
Description		inosine monophosphate dehydrogenase 1	inosine monophosphate dehydrogenase 2
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GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Cytosol Secretory Granule Lumen Azurophil Granule Lumen Ficolin-1-rich Granule Lumen	Extracellular Region Nucleus Cytoplasm Peroxisomal Membrane Cytosol Membrane Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	Nucleotide Binding Nucleic Acid Binding DNA Binding RNA Binding IMP Dehydrogenase Activity Metal Ion Binding	Nucleotide Binding DNA Binding RNA Binding IMP Dehydrogenase Activity Protein Binding Metal Ion Binding
	Biological Process	GMP Biosynthetic Process GTP Biosynthetic Process Purine Ribonucleoside Monophosphate Biosynthetic Process Neutrophil Degranulation	GMP Biosynthetic Process GTP Biosynthetic Process Circadian Rhythm Purine Ribonucleoside Monophosphate Biosynthetic Process Neutrophil Degranulation
Pathways		Neutrophil degranulation Purine ribonucleoside monophosphate biosynthesis Potential therapeutics for SARS	Neutrophil degranulation Purine ribonucleoside monophosphate biosynthesis Potential therapeutics for SARS
Drugs		NADH Mycophenolate mofetil Ribavirin Mycophenolic acid Mercaptopurine 6-Chloropurine Riboside, 5'-Monophosphate VX-148 Taribavirin	NADH Mycophenolate mofetil Ribavirin Mycophenolic acid Mercaptopurine Selenazole-4-carboxyamide-adenine dinucleotide 6-Chloropurine Riboside, 5'-Monophosphate Inosinic Acid VX-148
Diseases		Leber congenital amaurosis (LCR) Retinitis pigmentosa (RP)
GWAS		Pelvic organ prolapse ( 32184442)	Blood protein levels ( 28240269) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)
Interacting Genes		8 interacting genes: DDIT4L GMNN HTRA1 IMPDH2 PIAS2 RAD54L2 RNF4 UBE2I	15 interacting genes: AGR2 AKT1 ANKRD9 APIP CLK1 CPLANE2 IL1F10 IMPDH1 PIAS4 POU6F2 STAT3 SUMO2 SUMO4 TRAF2 UBQLN4
Entrez ID		3614	3615
HPRD ID		08853	00895
Ensembl ID		ENSG00000106348	ENSG00000178035
Uniprot IDs		B3KRZ3 P20839 Q6ZNB1	A0A384N6C2 P12268
PDB IDs		1JCN	1B3O 1NF7 1NFB 6I0M 6I0O 6U8E 6U8N 6U8R 6U8S 6U9O 6UA2 6UA4 6UA5 6UAJ 6UC2 6UDO 6UDP 6UDQ
Enriched GO Terms of Interacting Partners?
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