MAP2K5 and PDGFRA

Data Source:
BioGRID (fluorescent resonance energy transfer)

		MAP2K5	PDGFRA
Description		mitogen-activated protein kinase kinase 5	platelet derived growth factor receptor alpha
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GO Annotations	Cellular Component	Nucleus Spindle Cytosol	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Microvillus Cilium External Side Of Plasma Membrane Membrane Cell Junction Intrinsic Component Of Plasma Membrane Protein-containing Complex Receptor Complex
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Metal Ion Binding	Protein Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Platelet-derived Growth Factor Alpha-receptor Activity Vascular Endothelial Growth Factor-activated Receptor Activity Platelet-derived Growth Factor Receptor Binding Protein Binding ATP Binding Growth Factor Binding Vascular Endothelial Growth Factor Binding Protein Homodimerization Activity Protein-containing Complex Binding Platelet-derived Growth Factor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Activation Of MAPK Activity Signal Transduction Heart Development Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cell Growth Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Interleukin-8 Production Negative Regulation Of Heterotypic Cell-cell Adhesion Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Protein Metabolic Process Negative Regulation Of Response To Cytokine Stimulus ERK5 Cascade Cellular Response To Growth Factor Stimulus Cellular Response To Laminar Fluid Shear Stress Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	MAPK Cascade Luteinization In Utero Embryonic Development Cell Activation Hematopoietic Progenitor Cell Differentiation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Multicellular Organism Development Estrogen Metabolic Process Positive Regulation Of Cell Population Proliferation Negative Regulation Of Platelet Activation Positive Regulation Of Phospholipase C Activity Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Viral Process Peptidyl-tyrosine Phosphorylation Signal Transduction Involved In Regulation Of Gene Expression Extracellular Matrix Organization Lung Development Adrenal Gland Development Positive Regulation Of Cell Migration Male Genitalia Development Leydig Cell Differentiation Positive Regulation Of Kinase Activity Cellular Response To Reactive Oxygen Species Platelet-derived Growth Factor Receptor-alpha Signaling Pathway Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway Wound Healing Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Phosphatidylinositol 3-kinase Activity Protein Autophosphorylation Platelet-derived Growth Factor Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Fibroblast Proliferation Embryonic Digestive Tract Morphogenesis Embryonic Cranial Skeleton Morphogenesis Embryonic Skeletal System Morphogenesis White Fat Cell Differentiation Regulation Of Chemotaxis Positive Regulation Of Protein Kinase B Signaling Cardiac Myofibril Assembly Roof Of Mouth Development Face Morphogenesis Cell Chemotaxis Retina Vasculature Development In Camera-type Eye Positive Regulation Of ERK1 And ERK2 Cascade Platelet Aggregation Cellular Response To Amino Acid Stimulus Metanephric Glomerular Capillary Formation Regulation Of Actin Cytoskeleton Reorganization Regulation Of Mesenchymal Stem Cell Differentiation
Pathways		Signalling to ERK5	PIP3 activates AKT signaling Downstream signal transduction Signaling by PDGF Constitutive Signaling by Aberrant PI3K in Cancer RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants Signaling by PDGFRA extracellular domain mutants Imatinib-resistant PDGFR mutants Sunitinib-resistant PDGFR mutants Regorafenib-resistant PDGFR mutants Sorafenib-resistant PDGFR mutants PDGFR mutants bind TKIs
Drugs		Fostamatinib	Becaplermin Imatinib Sunitinib XL820 Olaratumab Pazopanib Midostaurin Regorafenib Ponatinib Lenvatinib Nintedanib Foreskin keratinocyte (neonatal) Fostamatinib Erdafitinib Amuvatinib Ripretinib
Diseases			Glioma
GWAS		Adult body size ( 32376654) Asthma ( 31959851) Bipolar disorder or body mass index ( 31754094) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body mass index ( 28552196 22344219 26961502 24861553 28892062 25673413 20935630 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index in physically active individuals ( 28448500) Body size at age 10 ( 32376654) Dental caries (decayed and filled deciduous teeth) ( 31533690) Menarche (age at onset) ( 25231870) Motion sickness ( 25628336) Obesity ( 23563607) Proportion of activated microglia (midfrontal cortex) ( 30679421) Restless legs syndrome ( 17637780 29029846 21779176) Smoking status (ever vs never smokers) ( 30643258) Triglyceride levels ( 32154731) Type 2 diabetes ( 30297969 32499647) Verbal declarative memory ( 25648963) Waist circumference ( 25673412) Weight ( 28552196)	Adult asthma ( 27611488) Asthma ( 27611488) Blood protein levels ( 30072576) Cadmium levels ( 26025379) Core binding factor acute myeloid leukemia ( 27903959) Corneal astigmatism ( 22144915 29422769) Corneal curvature ( 24963161 23401653 21665993) Height ( 18193045) Hematocrit ( 29403010) Hemoglobin ( 29403010) Lupus nephritis in systemic lupus erythematosus ( 24925725) Macular thickness ( 30535121) Mean corpuscular hemoglobin ( 29403010 20139978) Mean corpuscular volume ( 29403010 20139978) Platelet count ( 29403010) Post bronchodilator FEV1/FVC ratio ( 26634245) Pulse pressure ( 30578418) Red blood cell count ( 29403010 28453575 20139978) Serum VEGFR2 concentration ( 25411163) Systolic blood pressure ( 30578418) Uterine fibroids ( 30194396 31649266) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		55 interacting genes: AKT1 ARAF ARNT ASRGL1 BAD BECN1 C3orf36 CCND2 CD44 CDC42BPB CDK4 CDK6 CDKN2A CDKN2B CDKN2C DUSP21 EPHA2 ERBB2 ESRRA FGFR4 FZR1 GLIS2 GRM1 GUCD1 HGF HIF1A LATS2 LNX2 MAP2K3 MAP2K6 MAP3K2 MAP3K3 MAPK7 MDM4 MET MYC NF2 PARD6A PDGFRA PFDN5 PRKCI PRKCZ RAF1 RPL28 SQSTM1 STAMBP STK11 TEAD2 TERT TP53 TSC1 XRCC6 YWHAZ ZNF426 ZNF620	64 interacting genes: AKT1 ARNT AURKA BECN1 CAV1 CAV3 CBL CCND2 CD44 CDK4 CDK6 CDKN2A CDKN2B CDKN2C CRK CRKL EGFR EPHA2 ERBB2 ERBB3 FBXO25 FGFR4 FZR1 GRB14 GRM1 HGF ITGAV ITGB3 JAK1 KASH5 KDELR2 LATS2 MAP2K5 MYC NF2 PDGFA PDGFB PDGFC PDGFRB PIK3CA PIK3R1 PLCG1 PLPP6 PRMT5 PTPN11 RAF1 SHB SHF SLC9A3R1 SMURF1 SNX2 SNX4 SNX6 SRPK1 STAT1 STAT3 STAT5A STAT5B STK11 TERT TGFBR2 TP53 TTYH2 ULBP2
Entrez ID		5607	5156
HPRD ID		03951	01429
Ensembl ID		ENSG00000137764	ENSG00000134853
Uniprot IDs		A0A024R5X5 A0A024R5Y2 Q13163	P16234
PDB IDs		2NPT 2O2V 4IC7	1GQ5 5GRN 5K5X 6A32 6JOI 6JOJ 6JOK 6JOL
Enriched GO Terms of Interacting Partners?
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