PDGFRA and GRB14

  • Data Source:
  • HPRD (in vivo, in vitro)

PDGFRA

GRB14

Description platelet derived growth factor receptor alpha growth factor receptor bound protein 14
Image
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Adventurousness ( 30643258)
  • Blood pressure ( 24954895 21572416)
  • Body fat percentage ( 26833246 31453325)
  • Body fat percentage variance ( 31453325)
  • Body mass index ( 29381148 26426971)
  • Body mass index (age>50) ( 26426971)
  • Body mass index x sex x age interaction (4df test) ( 26426971)
  • Coronary artery disease ( 32469254 33020668)
  • Diastolic blood pressure ( 28739976 27618452)
  • Diastolic blood pressure (cigarette smoking interaction) ( 29455858)
  • Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962)
  • Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962)
  • Fasting blood insulin ( 25631608)
  • Fasting blood insulin (BMI interaction) ( 22581228)
  • Glomerular filtration rate in chronic kidney disease ( 26420894)
  • Glycine levels ( 30837465)
  • HDL cholesterol levels ( 30698716)
  • HDL cholesterol levels in current drinkers ( 30698716)
  • HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716)
  • HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)
  • Hip circumference ( 25673412)
  • Hip circumference adjusted for BMI ( 25673412)
  • Hypertension ( 30487518)
  • Immunoglobulin A vasculitis ( 28698626)
  • LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)
  • Mean arterial pressure ( 29403010 30487518)
  • Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962)
  • Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962)
  • Number of sexual partners ( 30643258)
  • Perceived sweetness of sucrose ( 31005972)
  • Pulse pressure ( 27841878 28739976 30487518)
  • Pulse pressure x alcohol consumption interaction (2df test) ( 29912962)
  • Response to statin therapy ( 20339536)
  • Sexual dimorphism in anthropometric traits ( 23754948)
  • Systolic blood pressure ( 26390057 28135244 27841878 29403010 28739976 27618447 27618452)
  • Systolic blood pressure (cigarette smoking interaction) ( 29455858)
  • Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962)
  • Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962)
  • Triglyceride levels ( 32203549 30698716)
  • Triglyceride levels in current drinkers ( 30698716)
  • Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716)
  • Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)
  • Type 2 diabetes ( 22885922 24509480 21874001 30297969 29632382 32499647 30718926 28869590)
  • Type 2 diabetes (adjusted for BMI) ( 29632382)
  • Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625)
  • Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500)
  • Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625)
  • Waist circumference adjusted for BMI in active individuals ( 28448500)
  • Waist circumference adjusted for BMI in non-smokers ( 28443625)
  • Waist circumference adjusted for body mass index ( 25673412 28448500)
  • Waist-hip ratio ( 25673412 20935629)
  • Waist-to-hip ratio adjusted for BMI ( 26426971)
  • Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625)
  • Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971)
  • Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971)
  • Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500)
  • Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625)
  • Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500)
  • Waist-to-hip ratio adjusted for BMI in inactive individuals ( 28448500)
  • Waist-to-hip ratio adjusted for BMI in non-smokers ( 28443625)
  • Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
  • Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500)
Interacting Genes 64 interacting genes: AKT1 ARNT AURKA BECN1 CAV1 CAV3 CBL CCND2 CD44 CDK4 CDK6 CDKN2A CDKN2B CDKN2C CRK CRKL EGFR EPHA2 ERBB2 ERBB3 FBXO25 FGFR4 FZR1 GRB14 GRM1 HGF ITGAV ITGB3 JAK1 KASH5 KDELR2 LATS2 MAP2K5 MYC NF2 PDGFA PDGFB PDGFC PDGFRB PIK3CA PIK3R1 PLCG1 PLPP6 PRMT5 PTPN11 RAF1 SHB SHF SLC9A3R1 SMURF1 SNX2 SNX4 SNX6 SRPK1 STAT1 STAT3 STAT5A STAT5B STK11 TERT TGFBR2 TP53 TTYH2 ULBP2 25 interacting genes: CDC5L CHFR DAPK3 EGFR ERBB2 FGFR1 FRS3 GIGYF1 GIGYF2 GOLGA2 HCK IGF1R INSR IRS1 MAP3K14 MET PDGFRA PDGFRB PRKCZ SQSTM1 STK26 TEK TNKS2 TRIM27 TRIM55
Entrez ID 5156 2888
HPRD ID 01429 03313
Ensembl ID ENSG00000134853 ENSG00000115290
Uniprot IDs P16234 Q14449
PDB IDs 1GQ5 5GRN 5K5X 6A32 6JOI 6JOJ 6JOK 6JOL 2AUG 2AUH 4K81
Enriched GO Terms of Interacting Partners?
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Tagcloud (Difference) ?
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