MAPK8 and MAPK8IP3

Data Source:
HPRD (in vivo, in vitro, two hybrid)

		MAPK8	MAPK8IP3
Description		mitogen-activated protein kinase 8	mitogen-activated protein kinase 8 interacting protein 3
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Axon Synapse Basal Dendrite	Golgi Membrane Cytoplasm Axon Dendrite Growth Cone Cytoplasmic Vesicle Cell Body Perinuclear Region Of Cytoplasm Axon Cytoplasm
	Molecular Function	Protein Serine/threonine Kinase Activity JUN Kinase Activity MAP Kinase Activity Protein Binding ATP Binding Kinase Activity Enzyme Binding Histone Deacetylase Regulator Activity Histone Deacetylase Binding	MAP-kinase Scaffold Activity Protein Binding JUN Kinase Binding Kinesin Binding Signaling Receptor Complex Adaptor Activity
	Biological Process	Protein Phosphorylation Response To Oxidative Stress JNK Cascade JUN Phosphorylation Response To UV Response To Mechanical Stimulus Positive Regulation Of Gene Expression Regulation Of Macroautophagy Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Regulation Of Histone Deacetylation Positive Regulation Of Cyclase Activity Negative Regulation Of Protein Binding Regulation Of Protein Localization Cellular Response To Amino Acid Starvation Cellular Response To Reactive Oxygen Species Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway Regulation Of Circadian Rhythm Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Rhythmic Process Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Protein Metabolic Process Stress-activated MAPK Cascade Cellular Response To Lipopolysaccharide Cellular Response To Mechanical Stimulus Cellular Response To Cadmium Ion Cellular Response To Cytokine Stimulus Positive Regulation Of Deacetylase Activity Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of DNA Replication Origin Binding	Activation Of JUN Kinase Activity Vesicle-mediated Transport Axon Regeneration Regulation Of JNK Cascade Axon Development Anterograde Axonal Protein Transport
Pathways		Activation of BIM and translocation to mitochondria Activation of BMF and translocation to mitochondria NRAGE signals death through JNK NRAGE signals death through JNK NRIF signals cell death from the nucleus Oxidative Stress Induced Senescence FCERI mediated MAPK activation DSCAM interactions JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Activation of the AP-1 family of transcription factors Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Interleukin-38 signaling WNT5:FZD7-mediated leishmania damping
Drugs		Tamoxifen Minocycline Pyrazolanthrone 6-CHLORO-9-HYDROXY-1,3-DIMETHYL-1,9-DIHYDRO-4H-PYRAZOLO[3,4-B]QUINOLIN-4-ONE 2-({2-[(3-HYDROXYPHENYL)AMINO]PYRIMIDIN-4-YL}AMINO)BENZAMIDE N-(4-AMINO-5-CYANO-6-ETHOXYPYRIDIN-2-YL)-2-(4-BROMO-2,5-DIMETHOXYPHENYL)ACETAMIDE 5-CYANO-N-(2,5-DIMETHOXYBENZYL)-6-ETHOXYPYRIDINE-2-CARBOXAMIDE 2-fluoro-6-{[2-({2-methoxy-4-[(methylsulfonyl)methyl]phenyl}amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino}benzamide Halicin
Diseases
GWAS		Blood protein levels in cardiovascular risk ( 28369058) Daytime sleep phenotypes ( 27126917) Refractive error ( 32231278)	Intraocular pressure ( 29617998)
Interacting Genes		137 interacting genes: AIMP1 AKT1 APBB2 APLP2 APP ATF2 BAD BCL2 BCL2L1 BCL2L11 BMF BMPR2 CAMP CASP3 CBL CCDC88C CDKN1A CDKN2A CDKN2C CEBPA COPS2 CRK CTNNB1 DUSP1 DUSP10 DUSP16 DUSP22 DUSP4 DUSP7 EEF2K EGFR ELK1 ELK3 ELK4 ELP1 EP300 ETV1 FAM193B FZR1 GANAB GARS1 GEMIN5 GFPT1 GORASP2 GSTP1 GUCY1A1 HDAC9 HIVEP1 HRAS HSD17B4 HSF1 HSF4 HSPA8 ID2 IL27RA IRAK1 IRF3 IRS1 ITCH JDP2 JKAMP JUN JUNB JUND KRT8 MAP1B MAP2K1 MAP2K2 MAP2K4 MAP2K7 MAP3K2 MAP3K7 MAPK1 MAPK14 MAPK3 MAPK8IP1 MAPK8IP2 MAPK8IP3 MAPKAP1 MAPKBP1 MAPT MBP MKNK2 MYC NCOA3 NFATC3 NFATC4 NFE2 NFE2L2 NKAPD1 NR3C1 NR4A1 PAX2 PDPK1 PIAS2 PIK3R1 PKMYT1 PNRC1 PPARG PRKD1 PRKDC PXN RAD18 RAF1 RASSF1 RBM15 REL RET RPLP2 RPS6KB1 SCAND1 SCOC SERPINB3 SERPINB4 SH3BP5 SHC1 SIRT1 SMAD2 SMAD3 SNCG SP1 SPAG9 SPI1 SPIB SSU72 STAT3 TFCP2 TNFSF11 TP53 TP73 TRAF6 WDR62 WWOX XRCC6 YWHAZ ZNF219 ZNF605	26 interacting genes: ARL4D CASP3 KLC1 KLC2 LDLRAP1 MAP2K1 MAP2K4 MAP2K7 MAP3K11 MAP3K5 MAPK10 MAPK8 MAPK8IP1 MAPK8IP2 MAPK9 PTK2 RAD51 RAD51D RAF1 RIC8A SRC SULT4A1 TLR2 TLR4 TLR9 ZNF575
Entrez ID		5599	23162
HPRD ID		03100	12014
Ensembl ID		ENSG00000107643	ENSG00000138834
Uniprot IDs		A1L4K2 P45983	A0A087WYG2 B7ZMF3 E9PFH7 Q9UPT6
PDB IDs		1UKH 1UKI 2G01 2GMX 2H96 2NO3 2XRW 2XS0 3ELJ 3O17 3O2M 3PZE 3V3V 3VUD 3VUG 3VUH 3VUI 3VUK 3VUL 3VUM 4AWI 4E73 4G1W 4HYS 4HYU 4IZY 4L7F 4QTD 4UX9 4YR8 5LW1 6F5E	4PXJ
Enriched GO Terms of Interacting Partners?
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