MAPK8 and NFATC4

Data Source:
BioGRID (enzymatic study)

		MAPK8	NFATC4
Description		mitogen-activated protein kinase 8	nuclear factor of activated T cells 4
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Axon Synapse Basal Dendrite	Chromatin Nucleus Transcription Regulator Complex Cytosol Nuclear Speck
	Molecular Function	Protein Serine/threonine Kinase Activity JUN Kinase Activity MAP Kinase Activity Protein Binding ATP Binding Kinase Activity Enzyme Binding Histone Deacetylase Regulator Activity Histone Deacetylase Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Protein Binding Transcription Factor Binding Peroxisome Proliferator Activated Receptor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Protein Phosphorylation Response To Oxidative Stress JNK Cascade JUN Phosphorylation Response To UV Response To Mechanical Stimulus Positive Regulation Of Gene Expression Regulation Of Macroautophagy Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Regulation Of Histone Deacetylation Positive Regulation Of Cyclase Activity Negative Regulation Of Protein Binding Regulation Of Protein Localization Cellular Response To Amino Acid Starvation Cellular Response To Reactive Oxygen Species Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway Regulation Of Circadian Rhythm Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Rhythmic Process Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Protein Metabolic Process Stress-activated MAPK Cascade Cellular Response To Lipopolysaccharide Cellular Response To Mechanical Stimulus Cellular Response To Cadmium Ion Cellular Response To Cytokine Stimulus Positive Regulation Of Deacetylase Activity Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of DNA Replication Origin Binding	Branching Involved In Blood Vessel Morphogenesis Cytokine Production Regulation Of Transcription By RNA Polymerase II Inflammatory Response Heart Development Long-term Memory Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Wnt Signaling Pathway Brain-derived Neurotrophic Factor Receptor Signaling Pathway Negative Regulation Of Protein Binding Positive Regulation Of Tumor Necrosis Factor Production Calcineurin-NFAT Signaling Cascade Cellular Response To UV Negative Regulation Of Chromatin Binding Negative Regulation Of Neuron Apoptotic Process Cellular Respiration Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Dendrite Morphogenesis Smooth Muscle Cell Differentiation Muscle Cell Development Long-term Synaptic Potentiation Cellular Response To Lithium Ion Negative Regulation Of Pri-miRNA Transcription By RNA Polymerase II Cellular Response To Ionomycin Negative Regulation Of Synapse Maturation Positive Regulation Of Apoptotic Signaling Pathway
Pathways		Activation of BIM and translocation to mitochondria Activation of BMF and translocation to mitochondria NRAGE signals death through JNK NRAGE signals death through JNK NRIF signals cell death from the nucleus Oxidative Stress Induced Senescence FCERI mediated MAPK activation DSCAM interactions JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Activation of the AP-1 family of transcription factors Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Interleukin-38 signaling WNT5:FZD7-mediated leishmania damping
Drugs		Tamoxifen Minocycline Pyrazolanthrone 6-CHLORO-9-HYDROXY-1,3-DIMETHYL-1,9-DIHYDRO-4H-PYRAZOLO[3,4-B]QUINOLIN-4-ONE 2-({2-[(3-HYDROXYPHENYL)AMINO]PYRIMIDIN-4-YL}AMINO)BENZAMIDE N-(4-AMINO-5-CYANO-6-ETHOXYPYRIDIN-2-YL)-2-(4-BROMO-2,5-DIMETHOXYPHENYL)ACETAMIDE 5-CYANO-N-(2,5-DIMETHOXYBENZYL)-6-ETHOXYPYRIDINE-2-CARBOXAMIDE 2-fluoro-6-{[2-({2-methoxy-4-[(methylsulfonyl)methyl]phenyl}amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino}benzamide Halicin
Diseases
GWAS		Blood protein levels in cardiovascular risk ( 28369058) Daytime sleep phenotypes ( 27126917) Refractive error ( 32231278)	Diastolic blood pressure ( 27841878) Height ( 20881960 25282103 23563607)
Interacting Genes		137 interacting genes: AIMP1 AKT1 APBB2 APLP2 APP ATF2 BAD BCL2 BCL2L1 BCL2L11 BMF BMPR2 CAMP CASP3 CBL CCDC88C CDKN1A CDKN2A CDKN2C CEBPA COPS2 CRK CTNNB1 DUSP1 DUSP10 DUSP16 DUSP22 DUSP4 DUSP7 EEF2K EGFR ELK1 ELK3 ELK4 ELP1 EP300 ETV1 FAM193B FZR1 GANAB GARS1 GEMIN5 GFPT1 GORASP2 GSTP1 GUCY1A1 HDAC9 HIVEP1 HRAS HSD17B4 HSF1 HSF4 HSPA8 ID2 IL27RA IRAK1 IRF3 IRS1 ITCH JDP2 JKAMP JUN JUNB JUND KRT8 MAP1B MAP2K1 MAP2K2 MAP2K4 MAP2K7 MAP3K2 MAP3K7 MAPK1 MAPK14 MAPK3 MAPK8IP1 MAPK8IP2 MAPK8IP3 MAPKAP1 MAPKBP1 MAPT MBP MKNK2 MYC NCOA3 NFATC3 NFATC4 NFE2 NFE2L2 NKAPD1 NR3C1 NR4A1 PAX2 PDPK1 PIAS2 PIK3R1 PKMYT1 PNRC1 PPARG PRKD1 PRKDC PXN RAD18 RAF1 RASSF1 RBM15 REL RET RPLP2 RPS6KB1 SCAND1 SCOC SERPINB3 SERPINB4 SH3BP5 SHC1 SIRT1 SMAD2 SMAD3 SNCG SP1 SPAG9 SPI1 SPIB SSU72 STAT3 TFCP2 TNFSF11 TP53 TP73 TRAF6 WDR62 WWOX XRCC6 YWHAZ ZNF219 ZNF605	12 interacting genes: CCNG1 CREBBP GATA4 GPR22 JUP MAPK14 MAPK8 MAPK9 NLGN3 NR1I2 YWHAQ YWHAZ
Entrez ID		5599	4776
HPRD ID		03100	09096
Ensembl ID		ENSG00000107643	ENSG00000100968
Uniprot IDs		A1L4K2 P45983	Q14934
PDB IDs		1UKH 1UKI 2G01 2GMX 2H96 2NO3 2XRW 2XS0 3ELJ 3O17 3O2M 3PZE 3V3V 3VUD 3VUG 3VUH 3VUI 3VUK 3VUL 3VUM 4AWI 4E73 4G1W 4HYS 4HYU 4IZY 4L7F 4QTD 4UX9 4YR8 5LW1 6F5E	2YRP
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?