MAPK3 and DCC

  • Data Source:
  • HPRD (in vivo, in vitro)

MAPK3

DCC

Description mitogen-activated protein kinase 3 DCC netrin 1 receptor
Image
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Age at first sexual intercourse ( 27089180)
  • Alcoholism (alcohol use disorder factor score) ( 21529783)
  • anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028)
  • Benign prostatic hyperplasia ( 30988330)
  • Body mass index ( 28892062)
  • Body mass index (ever vs never smoking interaction) ( 23192594)
  • Bortezomib-induced peripheral neuropathy in multiple myeloma ( 28317148)
  • Brain morphology (MOSTest) ( 32665545)
  • Chronic back pain ( 30261039)
  • Coenzyme Q10 levels ( 27149984)
  • Cognitive ability ( 29186694)
  • Cognitive ability (MTAG) ( 29186694)
  • Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203)
  • Depression ( 27089181 29700475)
  • Experiencing mood swings ( 29500382)
  • Feeling fed-up ( 29500382)
  • Feeling miserable ( 29500382)
  • Gallbladder cancer ( 22318345)
  • General cognitive ability ( 29844566)
  • General factor of neuroticism ( 30867560)
  • Glucose homeostasis traits ( 25524916)
  • Gut microbiota relative abundance (unclassified genus belonging to family Clostridiaceae) ( 33208821)
  • Household income (MTAG) ( 31844048)
  • Intelligence (MTAG) ( 29326435)
  • Intraocular pressure ( 30591961)
  • Lung function (FVC) ( 30061609 30804560)
  • Mood instability ( 31168069 29187730)
  • Mosquito bite size ( 28199695)
  • Multisite chronic pain ( 31194737)
  • Neurociticism ( 29500382)
  • Nickel levels ( 26025379)
  • Number of sexual partners ( 30643258)
  • Obesity-related traits ( 23251661)
  • Putamen volume ( 29147026)
  • Response to exercise (triglyceride level interaction) ( 26491034)
  • Response to fenofibrate (total cholesterol levels) ( 27002377)
  • Response to mTOR inhibitor (everolimus) ( 24009623)
  • Risk-taking tendency (4-domain principal component model) ( 30643258)
  • Schizophrenia ( 30285260)
  • Short-term memory (digit-span task) ( 30741946)
  • Smoking behaviour (cigarettes smoked per day) ( 27393504)
  • Smoking status (ever vs never smokers) ( 30643258)
  • Subcortical brain region volumes ( 25607358)
  • Survival in colorectal cancer (distant metastatic) ( 26586795)
Interacting Genes 186 interacting genes: AKR1C1 AMOT ARRB1 ATP1A1 AURKA BCL2 BCL3 BRAF BTBD10 BUB1 C1QBP CASP8 CASP9 CAV1 CCDC6 CDC23 CDC25C CDC45 CDH1 CDKN2A CEBPB CPXM1 CREBBP CREM CRP CTNND1 CUEDC2 DAPK1 DCC DCP1A DLC1 DUSP1 DUSP10 DUSP3 DUSP4 DUSP5 DUSP6 DUSP9 EGFR ELK1 ELK4 EPOR ESR1 ETS1 ETV1 FBXW7 FCGR2B FKBP2 FOS FOXP2 FRS2 GAB1 GAB2 GATA1 GATA4 GJA1 GMFB GRK2 GTF2I HDAC4 HDAC6 HIF1A HMMR HNF4A HSF1 HSF4 HSPB8 HTRA2 ID2 IER3 INSR IRS1 ITGAV ITGB3 JUN JUND KRT8 KSR2 L3MBTL3 LAMTOR3 LCK LIPE LRPAP1 LRRC4 LYN MAFG MAGEA11 MAGED1 MAP2K1 MAP2K2 MAP2K3 MAP3K14 MAPK14 MAPK8 MAPKAPK2 MAPT MBP MED1 METAP2 MKNK1 MYC MYLK MYOG NAB2 NCKIPSD NGFR NRAS NTRK1 NTRK3 NUP153 NUP58 PAK2 PDE6G PDGFRL PEA15 PFKM PLAT PLCB1 PPARA PPP1CA PPP2CA PRKCD PRKCE PRKCZ PTPN11 PTPN5 PTPN7 PTPRE PTPRR PXN RAB4A RAF1 RALGDS RB1 RCAN1 RET RNF114 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA4 RPS6KB1 RPTOR RXRA SCAND1 SCRIB SMAD2 SNCG SORBS3 SOS1 SOX2 SP1 SPIB SRC SREBF1 SREBF2 STAR STAT3 STAT5A STK11 STMN1 STMN2 STUB1 SULT4A1 SYK SYN1 SYNE2 TAL1 TAL2 TCF3 TGIF1 TH TNFSF11 TOP2B TP53 TRIM54 TSC2 TTYH3 UBE4B UBTF USP21 VDR VPS52 ZC3HC1 ZNF219 ZNF7 28 interacting genes: ADORA2B ALDOB ANP32B APPL1 AR BARD1 CASP3 CASP9 CORO2A CTSV FBP1 HEMGN MAPK3 MAZ NCK1 NTN1 PITPNA PTK2 RASA1 RPL5 SFRP2 SIAH1 SIAH2 TBC1D2 TDRD7 TMOD1 TRMO TSTD2
Entrez ID 5595 1630
HPRD ID 03479 00391
Ensembl ID ENSG00000102882 ENSG00000187323
Uniprot IDs L7RXH5 P27361 Q9BWJ1 P43146 Q49AK4
PDB IDs 2ZOQ 4QTB 6GES 2ED7 2ED8 2ED9 2EDB 2EDD 2EDE 3AU4 4URT 5X83
Enriched GO Terms of Interacting Partners?
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