MAPK3 and BRAF

Data Source:
BioGRID (imaging technique, two hybrid)

		MAPK3	BRAF
Description		mitogen-activated protein kinase 3	B-Raf proto-oncogene, serine/threonine kinase
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GO Annotations	Cellular Component	Nucleus Nuclear Envelope Nucleoplasm Cytoplasm Mitochondrion Early Endosome Late Endosome Golgi Apparatus Cytosol Cytoskeleton Plasma Membrane Caveola Focal Adhesion Pseudopodium Protein-containing Complex	Nucleus Cytosol Plasma Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Phosphotyrosine Residue Binding Protein Serine/threonine Kinase Activity MAP Kinase Activity MAP Kinase Kinase Activity Protein Binding ATP Binding Phosphatase Binding Identical Protein Binding Scaffold Protein Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Calcium Ion Binding Protein Binding ATP Binding Small GTPase Binding Identical Protein Binding Scaffold Protein Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	MAPK Cascade Activation Of MAPKK Activity Activation Of MAPK Activity Positive Regulation Of Protein Phosphorylation Transcription Initiation From RNA Polymerase I Promoter Protein Phosphorylation Apoptotic Process DNA Damage Induced Protein Phosphorylation Cell Cycle Cell Surface Receptor Signaling Pathway Axon Guidance Aging Fibroblast Growth Factor Receptor Signaling Pathway Response To Toxic Substance Positive Regulation Of Gene Expression Positive Regulation Of Macrophage Chemotaxis Regulation Of Phosphatidylinositol 3-kinase Signaling Viral Process Phosphorylation Peptidyl-serine Phosphorylation Sensory Perception Of Pain Arachidonic Acid Metabolic Process Platelet Activation Regulation Of Ossification BMP Signaling Pathway Regulation Of Cellular PH Thyroid Gland Development Positive Regulation Of Cyclase Activity Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Telomere Maintenance Via Telomerase Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Histone Phosphorylation Cellular Response To Amino Acid Starvation Cellular Response To Reactive Oxygen Species Positive Regulation Of Histone Acetylation Intracellular Signal Transduction Peptidyl-tyrosine Autophosphorylation Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Outer Ear Morphogenesis Response To Exogenous DsRNA Positive Regulation Of Translation Positive Regulation Of Transcription By RNA Polymerase II Decidualization Thymus Development Regulation Of DNA-binding Transcription Factor Activity Cartilage Development Stress-activated MAPK Cascade Regulation Of Cytoskeleton Organization Positive Regulation Of Telomerase Activity Bergmann Glial Cell Differentiation Face Development Lung Morphogenesis Trachea Formation Cardiac Neural Crest Cell Development Involved In Heart Development Protein-containing Complex Assembly ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Interleukin-1-mediated Signaling Pathway Response To Epidermal Growth Factor Cellular Response To Mechanical Stimulus Cellular Response To Cadmium Ion Cellular Response To Tumor Necrosis Factor Caveolin-mediated Endocytosis Regulation Of Golgi Inheritance Positive Regulation Of Macrophage Proliferation Regulation Of Cellular Response To Heat Cellular Response To Dopamine Positive Regulation Of Telomere Capping Positive Regulation Of Xenophagy Regulation Of Early Endosome To Late Endosome Transport Negative Regulation Of Apolipoprotein Binding	MAPK Cascade Activation Of MAPKK Activity Protein Phosphorylation Epidermal Growth Factor Receptor Signaling Pathway Animal Organ Morphogenesis Positive Regulation Of Gene Expression Positive Regulation Of Glucose Transmembrane Transport Positive Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Apoptotic Process Positive Regulation Of ERK1 And ERK2 Cascade Trehalose Metabolism In Response To Stress Cellular Response To Calcium Ion Establishment Of Protein Localization To Membrane
Pathways		MAPK3 (ERK1) activation RAF-independent MAPK1/3 activation ISG15 antiviral mechanism Spry regulation of FGF signaling Frs2-mediated activation ERK/MAPK targets ERK/MAPK targets ERKs are inactivated Regulation of actin dynamics for phagocytic cup formation Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) Oncogene Induced Senescence Oncogene Induced Senescence FCERI mediated MAPK activation Regulation of HSF1-mediated heat shock response NCAM signaling for neurite out-growth RSK activation Signal transduction by L1 Activation of the AP-1 family of transcription factors Thrombin signalling through proteinase activated receptors (PARs) Negative regulation of FGFR1 signaling Negative regulation of FGFR2 signaling Negative regulation of FGFR3 signaling Negative regulation of FGFR4 signaling RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate NADPH Oxidases RAF/MAP kinase cascade MAP2K and MAPK activation Negative feedback regulation of MAPK pathway Negative regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling RNA Polymerase I Promoter Opening Signal attenuation Advanced glycosylation endproduct receptor signaling Gastrin-CREB signalling pathway via PKC and MAPK ESR-mediated signaling RUNX2 regulates osteoblast differentiation Regulation of PTEN gene transcription Regulation of the apoptosome activity Estrogen-dependent nuclear events downstream of ESR-membrane signaling Suppression of apoptosis Signaling downstream of RAS mutants Signaling by MAP2K mutants Signaling by RAF1 mutants FCGR3A-mediated phagocytosis Growth hormone receptor signaling	Spry regulation of FGF signaling Frs2-mediated activation Frs2-mediated activation ARMS-mediated activation Signalling to p38 via RIT and RIN RAF activation MAP2K and MAPK activation Negative feedback regulation of MAPK pathway Negative regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants Signaling by MRAS-complex mutants
Drugs		Sulindac Acetylsalicylic acid Minocycline Arsenic trioxide Purvalanol 5-iodotubercidin Seliciclib Cholecystokinin Ulixertinib	Sorafenib XL281 RAF-265 PLX-4720 N-{2,4-difluoro-3-[(5-pyridin-3-yl-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]phenyl}ethanesulfonamide (1E)-5-(1-piperidin-4-yl-3-pyridin-4-yl-1H-pyrazol-4-yl)-2,3-dihydro-1H-inden-1-one oxime Vemurafenib Regorafenib Dabrafenib Encorafenib Fostamatinib Ripretinib
Diseases			Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS) Thyroid cancer Malignant melanoma
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 30072576) Brain morphology (MOSTest) ( 32665545) Childhood body mass index ( 33045005) Hodgkin's lymphoma ( 30194254) Multiple sclerosis ( 31604244 24076602) Pubertal anthropometrics ( 23449627) Schizophrenia ( 28991256 25056061 29483656) Tonsillectomy ( 27182965 28928442) Waist circumference ( 28552196) Weight ( 28552196)	anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Bipolar disorder ( 31043756) Cerebrospinal fluid t-tau:AB1-42 ratio ( 26252872) Cerebrospinal T-tau levels ( 26252872) Mild influenza (H1N1) infection ( 26379185) Response to Vitamin E supplementation ( 22437554) Type 2 diabetes ( 32499647 28869590)
Interacting Genes		186 interacting genes: AKR1C1 AMOT ARRB1 ATP1A1 AURKA BCL2 BCL3 BRAF BTBD10 BUB1 C1QBP CASP8 CASP9 CAV1 CCDC6 CDC23 CDC25C CDC45 CDH1 CDKN2A CEBPB CPXM1 CREBBP CREM CRP CTNND1 CUEDC2 DAPK1 DCC DCP1A DLC1 DUSP1 DUSP10 DUSP3 DUSP4 DUSP5 DUSP6 DUSP9 EGFR ELK1 ELK4 EPOR ESR1 ETS1 ETV1 FBXW7 FCGR2B FKBP2 FOS FOXP2 FRS2 GAB1 GAB2 GATA1 GATA4 GJA1 GMFB GRK2 GTF2I HDAC4 HDAC6 HIF1A HMMR HNF4A HSF1 HSF4 HSPB8 HTRA2 ID2 IER3 INSR IRS1 ITGAV ITGB3 JUN JUND KRT8 KSR2 L3MBTL3 LAMTOR3 LCK LIPE LRPAP1 LRRC4 LYN MAFG MAGEA11 MAGED1 MAP2K1 MAP2K2 MAP2K3 MAP3K14 MAPK14 MAPK8 MAPKAPK2 MAPT MBP MED1 METAP2 MKNK1 MYC MYLK MYOG NAB2 NCKIPSD NGFR NRAS NTRK1 NTRK3 NUP153 NUP58 PAK2 PDE6G PDGFRL PEA15 PFKM PLAT PLCB1 PPARA PPP1CA PPP2CA PRKCD PRKCE PRKCZ PTPN11 PTPN5 PTPN7 PTPRE PTPRR PXN RAB4A RAF1 RALGDS RB1 RCAN1 RET RNF114 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA4 RPS6KB1 RPTOR RXRA SCAND1 SCRIB SMAD2 SNCG SORBS3 SOS1 SOX2 SP1 SPIB SRC SREBF1 SREBF2 STAR STAT3 STAT5A STK11 STMN1 STMN2 STUB1 SULT4A1 SYK SYN1 SYNE2 TAL1 TAL2 TCF3 TGIF1 TH TNFSF11 TOP2B TP53 TRIM54 TSC2 TTYH3 UBE4B UBTF USP21 VDR VPS52 ZC3HC1 ZNF219 ZNF7	46 interacting genes: AKT1 ARAF AURKA BAD CCDC88A CTSV FBP1 HRAS HSD17B3 ITCH KRAS LATS2 MAP2K1 MAP2K2 MAP2K3 MAP2K6 MAPK1 MAPK3 MRAS NANOG OIP5 PAK2 PEBP1 PPP2CA PPP2R2A PRKACA PRKCE RAF1 RAP1A RAP1GAP RASSF1 RHEB SFN SGK1 SPRY2 STK11 TERF1 TERT UBE2L3 YWHAB YWHAG YWHAH YWHAQ YWHAZ ZNF189 ZNF510
Entrez ID		5595	673
HPRD ID		03479	01264
Ensembl ID		ENSG00000102882	ENSG00000157764
Uniprot IDs		L7RXH5 P27361 Q9BWJ1	P15056
PDB IDs		2ZOQ 4QTB 6GES	1UWH 1UWJ 2FB8 2L05 3C4C 3D4Q 3IDP 3II5 3NY5 3OG7 3PPJ 3PPK 3PRF 3PRI 3PSB 3PSD 3Q4C 3Q96 3SKC 3TV4 3TV6 4CQE 4DBN 4E26 4E4X 4EHE 4EHG 4FC0 4FK3 4G9C 4G9R 4H58 4JVG 4KSP 4KSQ 4MBJ 4MNE 4MNF 4PP7 4R5Y 4RZV 4RZW 4WO5 4XV1 4XV2 4XV3 4XV9 4YHT 5C9C 5CSW 5CSX 5CT7 5FD2 5HI2 5HID 5HIE 5ITA 5J17 5J18 5J2R 5JRQ 5JSM 5JT2 5VAL 5VAM 5VR3 5VYK 6B8U 6CAD 6N0P 6N0Q 6NSQ 6NYB 6P3D 6P7G 6PP9 6Q0J 6Q0K 6Q0T 6U2G 6U2H 6UAN 6UUO 6XAG
Enriched GO Terms of Interacting Partners?
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