DCC and NTN1

Data Source:
HPRD (in vitro)

		DCC	NTN1
Description		DCC netrin 1 receptor	netrin 1
Image
GO Annotations	Cellular Component	Cytosol Plasma Membrane Axon Schaffer Collateral - CA1 Synapse Integral Component Of Postsynaptic Density Membrane	Extracellular Region Basement Membrane Cytoplasm
	Molecular Function	Transmembrane Signaling Receptor Activity Netrin Receptor Activity Protein Binding	Protein Binding
	Biological Process	Neuron Migration Apoptotic Process Axonogenesis Axon Guidance Negative Regulation Of Neuron Projection Development Spinal Cord Ventral Commissure Morphogenesis Dorsal/ventral Axon Guidance Anterior/posterior Axon Guidance Netrin-activated Signaling Pathway Negative Regulation Of Collateral Sprouting Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Postsynaptic Modulation Of Chemical Synaptic Transmission Regulation Of Neuron Death Negative Regulation Of Netrin-activated Signaling Pathway Negative Regulation Of Dendrite Development	Neuron Migration Apoptotic Process Substrate-dependent Cell Migration, Cell Extension Nuclear Migration Ras Protein Signal Transduction Motor Neuron Axon Guidance Positive Regulation Of Cell Population Proliferation Animal Organ Morphogenesis Tissue Development Dendrite Development Regulation Of Cell Migration Negative Regulation Of Axon Extension Cdc42 Protein Signal Transduction Anterior/posterior Axon Guidance Inner Ear Morphogenesis Positive Regulation Of Axon Extension Regulation Of Synapse Assembly Mammary Gland Duct Morphogenesis Chemorepulsion Of Axon Cell-cell Adhesion Negative Regulation Of Netrin-activated Signaling Pathway Positive Regulation Of Cell Motility
Pathways		Netrin-1 signaling Netrin-1 signaling DSCAM interactions DCC mediated attractive signaling DCC mediated attractive signaling Netrin mediated repulsion signals Caspase activation via Dependence Receptors in the absence of ligand Role of second messengers in netrin-1 signaling Regulation of commissural axon pathfinding by SLIT and ROBO	Netrin-1 signaling Netrin-1 signaling DSCAM interactions DCC mediated attractive signaling DCC mediated attractive signaling Netrin mediated repulsion signals Role of second messengers in netrin-1 signaling Regulation of commissural axon pathfinding by SLIT and ROBO
Drugs
Diseases		Colorectal cancer Gastric cancer Cancer of the anal canal
GWAS		Age at first sexual intercourse ( 27089180) Alcoholism (alcohol use disorder factor score) ( 21529783) anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Benign prostatic hyperplasia ( 30988330) Body mass index ( 28892062) Body mass index (ever vs never smoking interaction) ( 23192594) Bortezomib-induced peripheral neuropathy in multiple myeloma ( 28317148) Brain morphology (MOSTest) ( 32665545) Chronic back pain ( 30261039) Coenzyme Q10 levels ( 27149984) Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Depression ( 27089181 29700475) Experiencing mood swings ( 29500382) Feeling fed-up ( 29500382) Feeling miserable ( 29500382) Gallbladder cancer ( 22318345) General cognitive ability ( 29844566) General factor of neuroticism ( 30867560) Glucose homeostasis traits ( 25524916) Gut microbiota relative abundance (unclassified genus belonging to family Clostridiaceae) ( 33208821) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Intraocular pressure ( 30591961) Lung function (FVC) ( 30061609 30804560) Mood instability ( 31168069 29187730) Mosquito bite size ( 28199695) Multisite chronic pain ( 31194737) Neurociticism ( 29500382) Nickel levels ( 26025379) Number of sexual partners ( 30643258) Obesity-related traits ( 23251661) Putamen volume ( 29147026) Response to exercise (triglyceride level interaction) ( 26491034) Response to fenofibrate (total cholesterol levels) ( 27002377) Response to mTOR inhibitor (everolimus) ( 24009623) Risk-taking tendency (4-domain principal component model) ( 30643258) Schizophrenia ( 30285260) Short-term memory (digit-span task) ( 30741946) Smoking behaviour (cigarettes smoked per day) ( 27393504) Smoking status (ever vs never smokers) ( 30643258) Subcortical brain region volumes ( 25607358) Survival in colorectal cancer (distant metastatic) ( 26586795)	Bisphosphonate-associated atypical femoral fracture ( 31006051) Blood protein levels ( 30072576 29875488) Brain morphology (MOSTest) ( 32665545) Breast cancer (prognosis) ( 23319801) Cleft lip with or without cleft palate ( 28054174) Cortex volume ( 31530798) Feeling hurt ( 29500382) Heel bone mineral density ( 30598549 28869591) Nonsyndromic cleft lip with cleft palate ( 28232668) Nonsyndromic cleft lip with or without cleft palate ( 25775280) Orofacial clefts ( 33137956 28054174) Percentage gas trapping ( 26030696) Rostral middle frontal gyrus volume ( 31530798) Total grey matter volume ( 31530798)
Interacting Genes		28 interacting genes: ADORA2B ALDOB ANP32B APPL1 AR BARD1 CASP3 CASP9 CORO2A CTSV FBP1 HEMGN MAPK3 MAZ NCK1 NTN1 PITPNA PTK2 RASA1 RPL5 SFRP2 SIAH1 SIAH2 TBC1D2 TDRD7 TMOD1 TRMO TSTD2	5 interacting genes: ADORA2B DCC NEO1 UNC5A UNC5C
Entrez ID		1630	9423
HPRD ID		00391	03368
Ensembl ID		ENSG00000187323	ENSG00000065320
Uniprot IDs		P43146 Q49AK4	O95631
PDB IDs		2ED7 2ED8 2ED9 2EDB 2EDD 2EDE 3AU4 4URT 5X83	4URT 6FKQ
Enriched GO Terms of Interacting Partners?
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