ERBIN and ATP2B4

Data Source:
BioGRID (unspecified method)

		ERBIN	ATP2B4
Description		erbb2 interacting protein	ATPase plasma membrane Ca2+ transporting 4
Image
GO Annotations	Cellular Component	Basement Membrane Nucleus Cytoplasm Plasma Membrane Basal Plasma Membrane Basolateral Plasma Membrane Nuclear Speck Cell Junction Hemidesmosome Nuclear Membrane Postsynapse Glutamatergic Synapse	Plasma Membrane Integral Component Of Plasma Membrane Caveola Membrane Basolateral Plasma Membrane Z Disc T-tubule Protein-containing Complex Sperm Flagellum Neuron Projection Intracellular Membrane-bounded Organelle Membrane Raft Sperm Principal Piece Glutamatergic Synapse Integral Component Of Presynaptic Active Zone Membrane
	Molecular Function	Signaling Receptor Binding ErbB-2 Class Receptor Binding Structural Constituent Of Cytoskeleton Protein Binding	Calcium Transmembrane Transporter Activity, Phosphorylative Mechanism Protein Binding Calmodulin Binding ATP Binding Calcium Ion Transmembrane Transporter Activity Sodium Channel Regulator Activity ATPase-coupled Cation Transmembrane Transporter Activity Protein Kinase Binding PDZ Domain Binding Protein Phosphatase 2B Binding Nitric-oxide Synthase Inhibitor Activity Metal Ion Binding Calcium-dependent Protein Binding Nitric-oxide Synthase Binding Scaffold Protein Binding
	Biological Process	Protein Targeting Cell Adhesion Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Integrin-mediated Signaling Pathway Negative Regulation Of NF-kappaB Transcription Factor Activity Response To Muramyl Dipeptide Response To Lipopolysaccharide ERBB2 Signaling Pathway Intermediate Filament Cytoskeleton Organization Basal Protein Localization Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Ras Protein Signal Transduction Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Cellular Response To Tumor Necrosis Factor Negative Regulation Of Monocyte Chemotactic Protein-1 Production Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels	Neural Retina Development Regulation Of Transcription By RNA Polymerase II Cellular Calcium Ion Homeostasis Spermatogenesis Negative Regulation Of Gene Expression Negative Regulation Of Nitric Oxide Mediated Signal Transduction Urinary Bladder Smooth Muscle Contraction Negative Regulation Of Angiogenesis Hippocampus Development Flagellated Sperm Motility Positive Regulation Of Peptidyl-serine Phosphorylation Ion Transmembrane Transport Negative Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Nitric Oxide Biosynthetic Process Negative Regulation Of Nitric-oxide Synthase Activity Regulation Of Cytosolic Calcium Ion Concentration Response To Hydrostatic Pressure Calcium Ion Transmembrane Transport Negative Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To Epinephrine Stimulus Calcium Ion Transmembrane Import Into Cytosol Calcium Ion Import Across Plasma Membrane Negative Regulation Of The Force Of Heart Contraction Negative Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Involved In Heart Process Transport Across Blood-brain Barrier Negative Regulation Of Arginine Catabolic Process Calcium Ion Export Negative Regulation Of Peptidyl-cysteine S-nitrosylation Regulation Of Sodium Ion Transmembrane Transport Negative Regulation Of Cellular Response To Vascular Endothelial Growth Factor Stimulus Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Negative Regulation Of Citrulline Biosynthetic Process Regulation Of Cardiac Conduction Cellular Response To Acetylcholine Positive Regulation Of CAMP-dependent Protein Kinase Activity
Pathways		Signaling by ERBB2 Downregulation of ERBB2 signaling Constitutive Signaling by Overexpressed ERBB2 Drug-mediated inhibition of ERBB2 signaling Signaling by ERBB2 KD Mutants Resistance of ERBB2 KD mutants to trastuzumab Resistance of ERBB2 KD mutants to sapitinib Resistance of ERBB2 KD mutants to tesevatinib Resistance of ERBB2 KD mutants to neratinib Resistance of ERBB2 KD mutants to osimertinib Resistance of ERBB2 KD mutants to afatinib Resistance of ERBB2 KD mutants to AEE788 Resistance of ERBB2 KD mutants to lapatinib Signaling by ERBB2 ECD mutants Signaling by ERBB2 TMD/JMD mutants Drug resistance in ERBB2 TMD/JMD mutants	Reduction of cytosolic Ca++ levels Ion homeostasis Ion transport by P-type ATPases
Drugs			Halothane Desflurane
Diseases
GWAS			Breast size ( 22747683) Composite immunoglobulin trait (IgA x IgG/IgM) ( 28628107) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Immature fraction of reticulocytes ( 32888494) Lymphocyte counts ( 32888494 27863252) Malaria ( 22895189 31844061) Mean corpuscular hemoglobin concentration ( 23263863 32888494 28453575 27863252) Mean corpuscular volume ( 32888494 27863252) Monocyte count ( 32888494) Obstructive sleep apnea (average oxygen saturation during sleep) ( 26977737) Plateletcrit ( 32888494) Red blood cell count ( 32888494) Red cell distribution width ( 32888494 27863252 28957414) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) White blood cell count ( 32888494)
Interacting Genes		66 interacting genes: ABCA1 ABCC4 ABR ACTN1 ACTN2 ACVR2A ACVR2B AGTR2 APC ARHGEF7 ARVCF ATP2B1 ATP2B2 ATP2B4 BANF1 CASK CDH1 CHUK COPB1 CTNNB1 CTNND1 CTNND2 CTSG DLG4 DST ERBB2 FOXO3 GRIN2B GRIN2C GUCY1A2 ITGB4 KCNA4 KCNA5 LAMB1 LMO1 LMO2 LRRC1 MAP4 MAPK12 MCC MEF2A MPP1 MPP2 MPP3 MUSK NOD2 NR2E1 PICK1 PKP4 RAF1 RBX1 RNF7 RPS6KA1 SCN4A SHOC2 SLC5A5 SLC5A6 SLC6A12 SMAD1 SMAD2 SMAD3 SMAD4 SMAD7 STAT3 VIPR2 ZFYVE9	11 interacting genes: CASK CD22 DLG1 DLG2 DLG3 DLG4 ERBIN NOS1 PPP3CA RASSF1 SRC
Entrez ID		55914	493
HPRD ID		06090	00159
Ensembl ID		ENSG00000112851	ENSG00000058668
Uniprot IDs		Q96RT1	A0A024R968 P23634
PDB IDs		1MFG 1MFL 1N7T 2H3L 2QBW 3CH8 6Q0M 6Q0N 6Q0U 6UBG 6UBH	1CFF 2KNE
Enriched GO Terms of Interacting Partners?
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