ERBIN and CTNNB1

Data Source:
BioGRID (affinity chromatography technology, unspecified method)

		ERBIN	CTNNB1
Description		erbb2 interacting protein	catenin beta 1
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GO Annotations	Cellular Component	Basement Membrane Nucleus Cytoplasm Plasma Membrane Basal Plasma Membrane Basolateral Plasma Membrane Nuclear Speck Cell Junction Hemidesmosome Nuclear Membrane Postsynapse Glutamatergic Synapse	Euchromatin Spindle Pole Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Centrosome Cytosol Plasma Membrane Cell-cell Junction Adherens Junction Focal Adhesion Cell Cortex Membrane Basolateral Plasma Membrane Lateral Plasma Membrane Catenin Complex Cell Junction Beta-catenin Destruction Complex Protein-containing Complex Protein-DNA Complex Cell Projection Synapse Perinuclear Region Of Cytoplasm Extracellular Exosome Beta-catenin-TCF7L2 Complex Cell Periphery Beta-catenin-TCF Complex Wnt Signalosome
	Molecular Function	Signaling Receptor Binding ErbB-2 Class Receptor Binding Structural Constituent Of Cytoskeleton Protein Binding	RNA Polymerase II Transcription Factor Binding RNA Polymerase II Activating Transcription Factor Binding Chromatin Binding Transcription Coactivator Activity Protein Binding Beta-catenin Binding Protein C-terminus Binding Transcription Factor Binding Enzyme Binding Kinase Binding Protein Phosphatase Binding Estrogen Receptor Binding Nuclear Hormone Receptor Binding Ion Channel Binding Alpha-catenin Binding Cadherin Binding SMAD Binding I-SMAD Binding
	Biological Process	Protein Targeting Cell Adhesion Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Integrin-mediated Signaling Pathway Negative Regulation Of NF-kappaB Transcription Factor Activity Response To Muramyl Dipeptide Response To Lipopolysaccharide ERBB2 Signaling Pathway Intermediate Filament Cytoskeleton Organization Basal Protein Localization Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Ras Protein Signal Transduction Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Cellular Response To Tumor Necrosis Factor Negative Regulation Of Monocyte Chemotactic Protein-1 Production Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels	Protein Polyubiquitination Branching Involved In Blood Vessel Morphogenesis Epithelial To Mesenchymal Transition Positive Regulation Of Neuroblast Proliferation Cell Adhesion Wnt Signaling Pathway, Calcium Modulating Pathway Negative Regulation Of Cell Population Proliferation Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Viral Process Wnt Signaling Pathway Negative Regulation Of Angiogenesis Stem Cell Population Maintenance Regulation Of Centriole-centriole Cohesion Response To Estradiol Positive Regulation Of Type I Interferon Production Negative Regulation Of Protein Sumoylation Adherens Junction Assembly Protein Localization To Cell Surface Hair Cell Differentiation Entry Of Bacterium Into Host Cell Detection Of Muscle Stretch Embryonic Skeletal Limb Joint Morphogenesis Response To Drug Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Neuron Apoptotic Process Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Canonical Wnt Signaling Pathway Involved In Negative Regulation Of Apoptotic Process Regulation Of Angiogenesis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Mitotic Cell Cycle, Embryonic Regulation Of Fibroblast Proliferation Regulation Of Smooth Muscle Cell Proliferation Regulation Of Neurogenesis Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Muscle Cell Differentiation Positive Regulation Of Histone H3-K4 Methylation Canonical Wnt Signaling Pathway Regulation Of Canonical Wnt Signaling Pathway Endothelial Tube Morphogenesis Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Cardiac Outflow Tract Cell Proliferation Sympathetic Ganglion Development Regulation Of Centromeric Sister Chromatid Cohesion Cellular Response To Growth Factor Stimulus Cellular Response To Indole-3-methanol Regulation Of Nephron Tubule Epithelial Cell Differentiation Regulation Of Calcium Ion Import Cell-cell Adhesion Positive Regulation Of Core Promoter Binding Beta-catenin-TCF Complex Assembly Beta-catenin Destruction Complex Disassembly Midbrain Dopaminergic Neuron Differentiation Canonical Wnt Signaling Pathway Involved In Midbrain Dopaminergic Neuron Differentiation Neuron Projection Extension Regulation Of Protein Localization To Cell Surface Positive Regulation Of DNA-templated Transcription, Initiation
Pathways		Signaling by ERBB2 Downregulation of ERBB2 signaling Constitutive Signaling by Overexpressed ERBB2 Drug-mediated inhibition of ERBB2 signaling Signaling by ERBB2 KD Mutants Resistance of ERBB2 KD mutants to trastuzumab Resistance of ERBB2 KD mutants to sapitinib Resistance of ERBB2 KD mutants to tesevatinib Resistance of ERBB2 KD mutants to neratinib Resistance of ERBB2 KD mutants to osimertinib Resistance of ERBB2 KD mutants to afatinib Resistance of ERBB2 KD mutants to AEE788 Resistance of ERBB2 KD mutants to lapatinib Signaling by ERBB2 ECD mutants Signaling by ERBB2 TMD/JMD mutants Drug resistance in ERBB2 TMD/JMD mutants	Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade TCF dependent signaling in response to WNT Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production Apoptotic cleavage of cell adhesion proteins Deactivation of the beta-catenin transactivating complex Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Ca2+ pathway Adherens junctions interactions Binding of TCF/LEF:CTNNB1 to target gene promoters Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane VEGFR2 mediated vascular permeability Myogenesis Myogenesis Signaling by GSK3beta mutants S33 mutants of beta-catenin aren't phosphorylated S37 mutants of beta-catenin aren't phosphorylated S45 mutants of beta-catenin aren't phosphorylated T41 mutants of beta-catenin aren't phosphorylated RHO GTPases activate IQGAPs Transcriptional Regulation by VENTX InlA-mediated entry of Listeria monocytogenes into host cells RUNX3 regulates WNT signaling
Drugs			Urea
Diseases			Gastric cancer Colorectal cancer Endometrial Cancer Pilomatricoma; Epithelioma calcificans of Malherbe Thyroid cancer Hepatocellular carcinoma
GWAS			Bone mineral density (hip) ( 27311723 19801982) Bone mineral density (total hip) ( 29883787) Colorectal cancer ( 26151821) Colorectal cancer or advanced adenoma ( 30510241) Femoral neck bone mineral density ( 29499414 22504420) Fractures ( 30158200) Heel bone mineral density ( 30598549 28869591) High myopia ( 31816047) Lumbar spine bone mineral density ( 29499414) Refractive error ( 32231278) Systolic blood pressure ( 30224653)
Interacting Genes		66 interacting genes: ABCA1 ABCC4 ABR ACTN1 ACTN2 ACVR2A ACVR2B AGTR2 APC ARHGEF7 ARVCF ATP2B1 ATP2B2 ATP2B4 BANF1 CASK CDH1 CHUK COPB1 CTNNB1 CTNND1 CTNND2 CTSG DLG4 DST ERBB2 FOXO3 GRIN2B GRIN2C GUCY1A2 ITGB4 KCNA4 KCNA5 LAMB1 LMO1 LMO2 LRRC1 MAP4 MAPK12 MCC MEF2A MPP1 MPP2 MPP3 MUSK NOD2 NR2E1 PICK1 PKP4 RAF1 RBX1 RNF7 RPS6KA1 SCN4A SHOC2 SLC5A5 SLC5A6 SLC6A12 SMAD1 SMAD2 SMAD3 SMAD4 SMAD7 STAT3 VIPR2 ZFYVE9	187 interacting genes: ACP1 AJAP1 AKT1 AMER1 APC APC2 APP AR ARFGEF1 ARHGAP32 ASH2L AXIN1 AXIN2 BCL3 BCL6 BCL9 BCL9L BOC BRCA1 BTRC CA9 CARM1 CASP3 CASP8 CBL CBY1 CCND1 CDC27 CDC34 CDC73 CDH1 CDH11 CDH15 CDH16 CDH2 CDH24 CDH3 CDH5 CDH7 CDH8 CDH9 CDK2 CDK5R1 CDK6 CDON CEBPA CHD8 CHUK CREBBP CSNK1A1 CSNK1D CSNK2A1 CSNK2B CTNNA1 CTNNA3 CTNNBIP1 CTNND2 DLG5 DSC3 DVL1 DVL3 EGFR ELAVL1 EP300 ERBB2 ERBIN ESR1 EZR FBXW2 FER FHIT FHL2 FLT1 FOXO1 FOXO4 FSCN1 FUS FYN GLIS2 GNA13 GRIK2 GRIN1 GRIN2D GSK3B H1-2 HIF1A HNF1A HUWE1 IGF2BP1 IKBKB IQGAP1 JADE1 KAT2A KAT2B KDR KMT2A KMT2D LATS2 LEF1 LEO1 MAGI1 MAGI2 MAP3K2 MAPK8 MAPK9 MEN1 MET MITF MUC1 NCOA2 NDRG1 NEK2 NEURL2 NF2 NFKB1 NOTCH1 NR5A1 PECAM1 PICK1 PIK3R1 PIN1 PITX2 PKD1 PKM PKP2 PLK1 PPM1A PRKCG PSEN1 PSEN2 PTGS2 PTPN1 PTPN13 PTPN14 PTPN6 PTPRF PTPRJ PTPRK PTPRM PTPRU PTPRZ1 PYGO1 RAPGEF2 RBBP5 RUVBL1 RUVBL2 RXRA SALL1 SLC9A3R1 SMAD2 SMAD3 SMAD4 SMAD7 SMARCA4 SMARCA5 SMURF1 SOX1 SOX17 SP1 SPN SRC STUB1 TAX1BP3 TBL1X TCF3 TCF4 TCF7L1 TCF7L2 TFAP2A TGFBR1 TGFBR2 TLE1 TRIM33 TRIM55 TRIM63 TRIP10 TRRAP UBE2B UBE2D1 UBE2R2 UBE2S UBE3A UHRF2 USP2 USP9X ZFYVE9 ZIC3
Entrez ID		55914	1499
HPRD ID		06090	00286
Ensembl ID		ENSG00000112851	ENSG00000168036
Uniprot IDs		Q96RT1	A0A024R2Q3 B4DGU4 P35222
PDB IDs		1MFG 1MFL 1N7T 2H3L 2QBW 3CH8 6Q0M 6Q0N 6Q0U 6UBG 6UBH	1G3J 1JDH 1JPW 1LUJ 1P22 1QZ7 1T08 1TH1 2G57 2GL7 2Z6H 3DIW 3FQN 3FQR 3SL9 3SLA 3TX7 4DJS 6M90 6M91 6M92 6M93 6M94 6O9B 6O9C 6WLX 6WNX
Enriched GO Terms of Interacting Partners?
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