PRKCQ and SELL

Data Source:
BioGRID (pull down)

		PRKCQ	SELL
Description		protein kinase C theta	selectin L
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GO Annotations	Cellular Component	Immunological Synapse Cytosol Plasma Membrane Aggresome Centriolar Satellite	Plasma Membrane Integral Component Of Plasma Membrane Secretory Granule Membrane
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Calcium-dependent Protein Kinase C Activity Protein Binding ATP Binding Metal Ion Binding	Protease Binding Calcium Ion Binding Protein Binding Heparin Binding Carbohydrate Binding Glycosphingolipid Binding Oligosaccharide Binding
	Biological Process	Regulation Of Cell Growth Regulation Of Transcription, DNA-templated Membrane Protein Ectodomain Proteolysis Inflammatory Response Axon Guidance Peptidyl-serine Phosphorylation Platelet Activation Positive Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Interleukin-17 Production Positive Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-4 Production Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway Positive Regulation Of T Cell Proliferation Regulation Of Megakaryocyte Differentiation Negative Regulation Of Insulin Receptor Signaling Pathway T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Activation Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Telomerase Activity Cell Chemotaxis Negative Regulation Of T Cell Apoptotic Process Regulation Of Platelet Aggregation Positive Regulation Of Telomere Capping Positive Regulation Of T-helper 17 Type Immune Response Positive Regulation Of T-helper 2 Cell Activation	Cell Adhesion Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Neutrophil Degranulation Regulation Of Immune Response Leukocyte Migration Leukocyte Tethering Or Rolling
Pathways		Apoptotic cleavage of cellular proteins Effects of PIP2 hydrolysis Downstream TCR signaling Inactivation, recovery and regulation of the phototransduction cascade FCERI mediated NF-kB activation FCERI mediated NF-kB activation Netrin-1 signaling G alpha (z) signalling events RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RAS processing	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Cell surface interactions at the vascular wall Neutrophil degranulation
Drugs		Tamoxifen Staurosporine Phosphonothreonine Dexfosfoserine Fostamatinib
Diseases		Type I diabetes mellitus
GWAS		Asthma ( 31959851 30929738) Asthma (bronchodilator response) ( 23508266) Asthma (childhood onset) ( 31036433 30929738) Autoimmune traits (pleiotropy) ( 30572963) Body mass index in asthmatics ( 23517042) Celiac disease ( 22057235 24999842) Celiac disease and Rheumatoid arthritis ( 26546613) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) Factor VII activity ( 30642921) Immune response to smallpox vaccine (IL-6) ( 22542470) Medication use (thyroid preparations) ( 31015401) Rheumatoid arthritis ( 30423114 18794853 24390342 20453842) Rheumatoid arthritis (ACPA-positive) ( 24532676) Type 1 diabetes ( 19430480 18978792)	Acne (severe) ( 24399259) Amyotrophic lateral sclerosis ( 19451621) Basophil percentage of white cells ( 32888494) Blood protein levels ( 30072576 29875488 28240269) Eosinophil percentage of white cells ( 32888494) Inflammatory bowel disease ( 26192919) L-selectin levels ( 25576479)
Interacting Genes		27 interacting genes: AKT1 BTK CARD11 CASP3 CBL CHUK CISH FYN GLRX3 GRM5 HABP4 ICAM3 IKBKB IKBKG IRS1 LCK LYN MARK3 MSN RASGRP3 SELL STK39 TAL1 VAV1 WIPF1 YWHAG YWHAQ	16 interacting genes: CD4 CFH EMCN EZR GRB2 MSN MUC7 PODXL PODXL2 PRKCA PRKCQ PRKG1 SELE SELPLG SLC30A2 VCAN
Entrez ID		5588	6402
HPRD ID		02710	07034
Ensembl ID		ENSG00000065675	ENSG00000188404
Uniprot IDs		Q04759	P14151
PDB IDs		1XJD 2ENJ 2ENN 2ENZ 2JED 4Q9Z 4RA5 5F9E	1KJB 2LGF 3CFW 5VC1
Enriched GO Terms of Interacting Partners?
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