PRKCQ and HABP4

Data Source:
HPRD (in vitro, in vivo)

		PRKCQ	HABP4
Description		protein kinase C theta	hyaluronan binding protein 4
Image			No pdb structure
GO Annotations	Cellular Component	Immunological Synapse Cytosol Plasma Membrane Aggresome Centriolar Satellite	Extracellular Region Nucleus Nucleoplasm Nucleolus Cytoplasm Golgi Apparatus Cytosol Cytoplasmic Stress Granule Cajal Body Sarcoplasm Nuclear Speck Sarcomere Gemini Of Coiled Bodies
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Calcium-dependent Protein Kinase C Activity Protein Binding ATP Binding Metal Ion Binding	RNA Binding Protein Binding SUMO Binding
	Biological Process	Regulation Of Cell Growth Regulation Of Transcription, DNA-templated Membrane Protein Ectodomain Proteolysis Inflammatory Response Axon Guidance Peptidyl-serine Phosphorylation Platelet Activation Positive Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Interleukin-17 Production Positive Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-4 Production Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway Positive Regulation Of T Cell Proliferation Regulation Of Megakaryocyte Differentiation Negative Regulation Of Insulin Receptor Signaling Pathway T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Activation Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Telomerase Activity Cell Chemotaxis Negative Regulation Of T Cell Apoptotic Process Regulation Of Platelet Aggregation Positive Regulation Of Telomere Capping Positive Regulation Of T-helper 17 Type Immune Response Positive Regulation Of T-helper 2 Cell Activation	Platelet Degranulation MRNA Processing RNA Splicing PML Body Organization Positive Regulation Of RNA Splicing Negative Regulation Of DNA Binding Positive Regulation Of Translational Initiation Cellular Response To Mechanical Stimulus
Pathways		Apoptotic cleavage of cellular proteins Effects of PIP2 hydrolysis Downstream TCR signaling Inactivation, recovery and regulation of the phototransduction cascade FCERI mediated NF-kB activation FCERI mediated NF-kB activation Netrin-1 signaling G alpha (z) signalling events RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RAS processing	Platelet degranulation
Drugs		Tamoxifen Staurosporine Phosphonothreonine Dexfosfoserine Fostamatinib	Hyaluronic acid
Diseases		Type I diabetes mellitus
GWAS		Asthma ( 31959851 30929738) Asthma (bronchodilator response) ( 23508266) Asthma (childhood onset) ( 31036433 30929738) Autoimmune traits (pleiotropy) ( 30572963) Body mass index in asthmatics ( 23517042) Celiac disease ( 22057235 24999842) Celiac disease and Rheumatoid arthritis ( 26546613) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) Factor VII activity ( 30642921) Immune response to smallpox vaccine (IL-6) ( 22542470) Medication use (thyroid preparations) ( 31015401) Rheumatoid arthritis ( 30423114 18794853 24390342 20453842) Rheumatoid arthritis (ACPA-positive) ( 24532676) Type 1 diabetes ( 19430480 18978792)	Height ( 25282103 31562340) Household income (MTAG) ( 31844048)
Interacting Genes		27 interacting genes: AKT1 BTK CARD11 CASP3 CBL CHUK CISH FYN GLRX3 GRM5 HABP4 ICAM3 IKBKB IKBKG IRS1 LCK LYN MARK3 MSN RASGRP3 SELL STK39 TAL1 VAV1 WIPF1 YWHAG YWHAQ	25 interacting genes: C1QBP CHD3 CRK DAXX ENO2 FRA10AC1 HMGXB4 KAT5 PIAS3 PPP1R15A PRKCA PRKCB PRKCD PRKCG PRKCQ PRKCZ PRMT1 RACK1 SRSF9 SYNCRIP TOPORS TP53 UBE2I VIM YBX1
Entrez ID		5588	22927
HPRD ID		02710	13628
Ensembl ID		ENSG00000065675	ENSG00000130956
Uniprot IDs		Q04759	Q5JVS0
PDB IDs		1XJD 2ENJ 2ENN 2ENZ 2JED 4Q9Z 4RA5 5F9E
Enriched GO Terms of Interacting Partners?
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