SELL and SELE

Data Source:
HPRD (in vitro)

		SELL	SELE
Description		selectin L	selectin E
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Secretory Granule Membrane	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Caveola Clathrin-coated Pit Cortical Cytoskeleton Membrane Raft Perinuclear Region Of Cytoplasm
	Molecular Function	Protease Binding Calcium Ion Binding Protein Binding Heparin Binding Carbohydrate Binding Glycosphingolipid Binding Oligosaccharide Binding	Transmembrane Signaling Receptor Activity Protein Binding Sialic Acid Binding Phospholipase Binding Metal Ion Binding Oligosaccharide Binding
	Biological Process	Cell Adhesion Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Neutrophil Degranulation Regulation Of Immune Response Leukocyte Migration Leukocyte Tethering Or Rolling	Positive Regulation Of Receptor Internalization Leukocyte Migration Involved In Inflammatory Response Inflammatory Response Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Activation Of Phospholipase C Activity Calcium-mediated Signaling Actin Filament-based Process Response To Lipopolysaccharide Response To Tumor Necrosis Factor Regulation Of Inflammatory Response Leukocyte Migration Leukocyte Tethering Or Rolling Response To Interleukin-1 Positive Regulation Of Leukocyte Tethering Or Rolling
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Cell surface interactions at the vascular wall Neutrophil degranulation	Cell surface interactions at the vascular wall
Drugs			Carvedilol N-acetyl-alpha-neuraminic acid Endostatin
Diseases
GWAS		Acne (severe) ( 24399259) Amyotrophic lateral sclerosis ( 19451621) Basophil percentage of white cells ( 32888494) Blood protein levels ( 30072576 29875488 28240269) Eosinophil percentage of white cells ( 32888494) Inflammatory bowel disease ( 26192919) L-selectin levels ( 25576479)	Blood protein levels ( 30072576) Inflammatory bowel disease ( 26192919) Monocyte percentage of white cells ( 32888494)
Interacting Genes		16 interacting genes: CD4 CFH EMCN EZR GRB2 MSN MUC7 PODXL PODXL2 PRKCA PRKCQ PRKG1 SELE SELPLG SLC30A2 VCAN	15 interacting genes: ACTA2 ACTN2 CD44 FLNA GLG1 LGALS3BP PLCG1 PTK2 PTPN11 PXN SELL SELPLG SERPING1 TRIM54 VCL
Entrez ID		6402	6401
HPRD ID		07034	00566
Ensembl ID		ENSG00000188404	ENSG00000007908
Uniprot IDs		P14151	P16581
PDB IDs		1KJB 2LGF 3CFW 5VC1	1ESL 1G1T 1KJA 4C16 4CSY 6EYI 6EYJ 6EYK
Enriched GO Terms of Interacting Partners?
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