PRKCE and KRT1

Data Source:
HPRD (in vivo)

		PRKCE	KRT1
Description		protein kinase C epsilon	keratin 1
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Endoplasmic Reticulum Golgi Apparatus Cytosol Plasma Membrane Intracellular Membrane-bounded Organelle Intermediate Filament Cytoskeleton Perinuclear Region Of Cytoplasm Cell Periphery	Cornified Envelope Extracellular Region Extracellular Space Nucleus Cytosol Cytoskeleton Membrane Keratin Filament Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle Ficolin-1-rich Granule Lumen
	Molecular Function	Actin Monomer Binding Protein Serine/threonine Kinase Activity Protein Kinase C Activity Calcium-dependent Protein Kinase C Activity Calcium-independent Protein Kinase C Activity Protein Binding ATP Binding Enzyme Activator Activity Enzyme Binding Signaling Receptor Activator Activity Ethanol Binding Metal Ion Binding 14-3-3 Protein Binding	Protein Binding Carbohydrate Binding Structural Constituent Of Skin Epidermis Signaling Receptor Activity Protein Heterodimerization Activity
	Biological Process	Macrophage Activation Involved In Immune Response Protein Phosphorylation Apoptotic Process Cell Cycle Cell Adhesion Signal Transduction Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Fibroblast Migration Positive Regulation Of Cell-substrate Adhesion Peptidyl-serine Phosphorylation Platelet Activation Positive Regulation Of Actin Filament Polymerization Negative Regulation Of Protein Ubiquitination Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Insulin Secretion Positive Regulation Of Synaptic Transmission, GABAergic Positive Regulation Of Cytokinesis Intracellular Signal Transduction Locomotory Exploration Behavior TRAM-dependent Toll-like Receptor 4 Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Morphine Positive Regulation Of MAPK Cascade Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Catalytic Activity Positive Regulation Of Lipid Catabolic Process Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Cell Division Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Mucus Secretion Cellular Response To Ethanol Cellular Response To Prostaglandin E Stimulus Cellular Response To Hypoxia Positive Regulation Of Wound Healing Positive Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Sodium Ion Transmembrane Transporter Activity Positive Regulation Of Cellular Glucuronidation	Complement Activation, Lectin Pathway Retina Homeostasis Response To Oxidative Stress Peptide Cross-linking Keratinization Fibrinolysis Neutrophil Degranulation Regulation Of Angiogenesis Negative Regulation Of Inflammatory Response Protein Heterotetramerization Establishment Of Skin Barrier Cornification
Pathways		Effects of PIP2 hydrolysis SHC1 events in ERBB2 signaling DAG and IP3 signaling Role of phospholipids in phagocytosis G alpha (z) signalling events	Neutrophil degranulation Keratinization Formation of the cornified envelope
Drugs		Tamoxifen KAI-1455 Bryostatin 1 Fostamatinib	Zinc Copper Zinc acetate
Diseases			Epidermolytic palmoplantar keratoderma (EPPK) Ichthyosis hystrix, Curth-Macklin type Epidermolytic hyperkeratosis (EHK); Bullous congenital ichthyosiform erythroderma (BCIE) Striate palmoplantar keratoderma
GWAS		Body mass index ( 28552196) Carotenoid levels (alpha-carotene) ( 28002826) Cerebral amyloid deposition in APOEe4 non-carriers (PET imaging) ( 26252872) Coronary artery disease ( 29212778 33020668) Corpus callosum posterior volume ( 31530798) Craniofacial microsomia ( 26853712) Diastolic blood pressure ( 28135244 30578418) Diisocyanate-induced asthma ( 25918132) Heel bone mineral density ( 30598549) Hematocrit ( 29403010 32888494 28453575 27863252 28017375 19862010) Hematological and biochemical traits ( 31902109 20139978) Hemoglobin ( 29403010 32888494 28453575 19862010) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693 28017375) High light scatter reticulocyte count ( 32888494 27863252) LDL cholesterol ( 30275531) Metabolite levels ( 23823483) Metabolite levels (X-11787) ( 23934736) Pathological gambling ( 27315593) Platelet count ( 32888494) Plateletcrit ( 32888494) Premature menopause in childhood cancer survivors ( 29432556) Pulse pressure ( 28135244 27841878 30578418) Red blood cell count ( 29403010 32888494 20139978 27863252 28017375) Red blood cell traits ( 23446634 23222517) Response to zileuton treatment in asthma (FEV1 change interaction) ( 26031901) Reticulocyte count ( 32888494) Suicide risk ( 21041247) Systolic blood pressure ( 30578418) Total cholesterol levels ( 30275531) Triiodothyronine levels ( 30824882) Two-hour glucose in pregnancy (gestational week 30-32) ( 30324795) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683) Weight ( 28552196) White blood cell count ( 32888494)
Interacting Genes		59 interacting genes: ACTA1 ACTC1 ADAP1 AFAP1 AKAP9 ATF2 BRAF BTK CFTR CHAT CNN1 COPB1 COPB2 DSP EGFR ELAVL1 FYN GAD1 GAD2 GJA1 GNA12 GNA13 GRIN1 GRIN2D GRM5 H1-1 HK2 IKBKB ITGB1 ITGB2 KRT1 KRT18 MAP4K4 MAPK1 MAPK3 MAPT MARK2 MYH2 NANOG NUMB OPRD1 PDLIM5 PDPK1 PECAM1 PIK3CB PPP1R14A PRKD1 RACK1 RAD9A RAF1 RASGRP3 RPS6KB2 SLC25A4 SLC4A3 SNCA SRC TIAM1 TRPV1 VDAC1	51 interacting genes: AMOTL2 CALB2 CSTA DSP EVPL F12 FANCA FANCC FFAR2 GOLGA2 GOLGA6L9 HAUS1 HMG20A HOOK2 IVL KNG1 KRT13 KRT14 KRT15 KRT16 KRT19 KRT24 KRT25 KRT26 KRT27 KRT28 KRT31 KRT33B KRT34 KRT35 KRT36 KRT37 KRT38 KRT39 KRT5 LINC00839 LORICRIN MBL2 NINL NUP62 PI3 PRKCE RINT1 SGTB TFIP11 TLCD4 TRIM54 U2AF1 U2AF1L5 UBE3A YWHAQ
Entrez ID		5581	3848
HPRD ID		01500	00763
Ensembl ID		ENSG00000171132	ENSG00000167768
Uniprot IDs		L7RTI5 Q02156	P04264
PDB IDs		2WH0 5LIH	4ZRY 6E2J 6UUI
Enriched GO Terms of Interacting Partners?
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