KRT1 and TLCD4

Data Source:
BioGRID (two hybrid)

		KRT1	TLCD4
Description		keratin 1	TLC domain containing 4
Image			No pdb structure
GO Annotations	Cellular Component	Cornified Envelope Extracellular Region Extracellular Space Nucleus Cytosol Cytoskeleton Membrane Keratin Filament Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle Ficolin-1-rich Granule Lumen	Cellular_component Endoplasmic Reticulum Integral Component Of Membrane
	Molecular Function	Protein Binding Carbohydrate Binding Structural Constituent Of Skin Epidermis Signaling Receptor Activity Protein Heterodimerization Activity	Molecular_function Protein Binding
	Biological Process	Complement Activation, Lectin Pathway Retina Homeostasis Response To Oxidative Stress Peptide Cross-linking Keratinization Fibrinolysis Neutrophil Degranulation Regulation Of Angiogenesis Negative Regulation Of Inflammatory Response Protein Heterotetramerization Establishment Of Skin Barrier Cornification	Biological_process Lipid Homeostasis
Pathways		Neutrophil degranulation Keratinization Formation of the cornified envelope
Drugs		Zinc Copper Zinc acetate
Diseases		Epidermolytic palmoplantar keratoderma (EPPK) Ichthyosis hystrix, Curth-Macklin type Epidermolytic hyperkeratosis (EHK); Bullous congenital ichthyosiform erythroderma (BCIE) Striate palmoplantar keratoderma
GWAS
Interacting Genes		51 interacting genes: AMOTL2 CALB2 CSTA DSP EVPL F12 FANCA FANCC FFAR2 GOLGA2 GOLGA6L9 HAUS1 HMG20A HOOK2 IVL KNG1 KRT13 KRT14 KRT15 KRT16 KRT19 KRT24 KRT25 KRT26 KRT27 KRT28 KRT31 KRT33B KRT34 KRT35 KRT36 KRT37 KRT38 KRT39 KRT5 LINC00839 LORICRIN MBL2 NINL NUP62 PI3 PRKCE RINT1 SGTB TFIP11 TLCD4 TRIM54 U2AF1 U2AF1L5 UBE3A YWHAQ	71 interacting genes: ADGRB3 ADGRE2 ARV1 ATP13A1 BNIP3 CACNG1 CCDC167 CDIPT CHPT1 CLCN7 CLEC7A CMTM5 COMT CTXN3 CXCL16 CYP4F2 CYP4F22 DHRSX EBP EMC6 EMP1 ERG28 FA2H FDFT1 FXYD6 FXYD6-FXYD2 GJB2 GOSR2 GYPA HMOX1 IGFBP5 KRT1 LNPEP MS4A13 MYG1 NAT8 NDUFA3 NINJ1 NKG7 ORMDL1 PMP22 PRAF2 PRRT2 REEP6 SCAMP5 SCD SEC22A SEC22B SERP1 SFXN1 SFXN3 SLC22A18 SLC41A1 SMAGP STATH STX12 SYNDIG1 SYNJ2BP TIMM23 TMEM115 TMEM120B TMEM19 TMEM229B TMEM237 TMEM60 TMIE TVP23B UBE2J1 VEZT YIPF1 YIPF4
Entrez ID		3848	148534
HPRD ID		00763	08110
Ensembl ID		ENSG00000167768	ENSG00000152078
Uniprot IDs		P04264	Q96MV1
PDB IDs		4ZRY 6E2J 6UUI
Enriched GO Terms of Interacting Partners?
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