PRKCE and CFTR

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vivo)

		PRKCE	CFTR
Description		protein kinase C epsilon	CF transmembrane conductance regulator
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Endoplasmic Reticulum Golgi Apparatus Cytosol Plasma Membrane Intracellular Membrane-bounded Organelle Intermediate Filament Cytoskeleton Perinuclear Region Of Cytoplasm Cell Periphery	Nucleus Cytoplasm Lysosomal Membrane Early Endosome Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Endosome Membrane Membrane Integral Component Of Membrane Apical Plasma Membrane Golgi-associated Vesicle Membrane Clathrin-coated Vesicle Membrane Early Endosome Membrane Protein-containing Complex Chloride Channel Complex Recycling Endosome Recycling Endosome Membrane
	Molecular Function	Actin Monomer Binding Protein Serine/threonine Kinase Activity Protein Kinase C Activity Calcium-dependent Protein Kinase C Activity Calcium-independent Protein Kinase C Activity Protein Binding ATP Binding Enzyme Activator Activity Enzyme Binding Signaling Receptor Activator Activity Ethanol Binding Metal Ion Binding 14-3-3 Protein Binding	Chloride Channel Activity Intracellularly ATP-gated Chloride Channel Activity Protein Binding ATP Binding Bicarbonate Transmembrane Transporter Activity Chloride Transmembrane Transporter Activity Isomerase Activity ATPase Activity Chloride Channel Regulator Activity Chloride Channel Inhibitor Activity Enzyme Binding PDZ Domain Binding ATPase-coupled Transmembrane Transporter Activity Chaperone Binding Sec61 Translocon Complex Binding
	Biological Process	Macrophage Activation Involved In Immune Response Protein Phosphorylation Apoptotic Process Cell Cycle Cell Adhesion Signal Transduction Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Fibroblast Migration Positive Regulation Of Cell-substrate Adhesion Peptidyl-serine Phosphorylation Platelet Activation Positive Regulation Of Actin Filament Polymerization Negative Regulation Of Protein Ubiquitination Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Insulin Secretion Positive Regulation Of Synaptic Transmission, GABAergic Positive Regulation Of Cytokinesis Intracellular Signal Transduction Locomotory Exploration Behavior TRAM-dependent Toll-like Receptor 4 Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Morphine Positive Regulation Of MAPK Cascade Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Catalytic Activity Positive Regulation Of Lipid Catabolic Process Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Cell Division Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Mucus Secretion Cellular Response To Ethanol Cellular Response To Prostaglandin E Stimulus Cellular Response To Hypoxia Positive Regulation Of Wound Healing Positive Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Sodium Ion Transmembrane Transporter Activity Positive Regulation Of Cellular Glucuronidation	Cholesterol Biosynthetic Process Vesicle Docking Involved In Exocytosis Bicarbonate Transport Protein Deubiquitination Cholesterol Transport Response To Endoplasmic Reticulum Stress Transepithelial Water Transport Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Exocytosis Sperm Capacitation Multicellular Organismal Water Homeostasis Intracellular PH Elevation Transmembrane Transport Membrane Hyperpolarization Membrane Organization Cellular Response To CAMP Positive Regulation Of Cyclic Nucleotide-gated Ion Channel Activity Chloride Transmembrane Transport Positive Regulation Of Voltage-gated Chloride Channel Activity Cellular Response To Forskolin
Pathways		Effects of PIP2 hydrolysis SHC1 events in ERBB2 signaling DAG and IP3 signaling Role of phospholipids in phagocytosis G alpha (z) signalling events	ABC-family proteins mediated transport RHO GTPases regulate CFTR trafficking Defective CFTR causes cystic fibrosis Ub-specific processing proteases Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Chaperone Mediated Autophagy Late endosomal microautophagy Aggrephagy Aggrephagy
Drugs		Tamoxifen KAI-1455 Bryostatin 1 Fostamatinib	ATP Bumetanide Glyburide Ibuprofen Colforsin Phosphoaminophosphonic Acid-Adenylate Ester Dexfosfoserine Crofelemer Lonidamine Ivacaftor Dexibuprofen Lumacaftor Tezacaftor Elexacaftor
Diseases			Cystic fibrosis (CF) Hereditary pancreatitis; Hereditary chronic pancreatitis Congenital bilateral absence of vas deferens
GWAS		Body mass index ( 28552196) Carotenoid levels (alpha-carotene) ( 28002826) Cerebral amyloid deposition in APOEe4 non-carriers (PET imaging) ( 26252872) Coronary artery disease ( 29212778 33020668) Corpus callosum posterior volume ( 31530798) Craniofacial microsomia ( 26853712) Diastolic blood pressure ( 28135244 30578418) Diisocyanate-induced asthma ( 25918132) Heel bone mineral density ( 30598549) Hematocrit ( 29403010 32888494 28453575 27863252 28017375 19862010) Hematological and biochemical traits ( 31902109 20139978) Hemoglobin ( 29403010 32888494 28453575 19862010) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693 28017375) High light scatter reticulocyte count ( 32888494 27863252) LDL cholesterol ( 30275531) Metabolite levels ( 23823483) Metabolite levels (X-11787) ( 23934736) Pathological gambling ( 27315593) Platelet count ( 32888494) Plateletcrit ( 32888494) Premature menopause in childhood cancer survivors ( 29432556) Pulse pressure ( 28135244 27841878 30578418) Red blood cell count ( 29403010 32888494 20139978 27863252 28017375) Red blood cell traits ( 23446634 23222517) Response to zileuton treatment in asthma (FEV1 change interaction) ( 26031901) Reticulocyte count ( 32888494) Suicide risk ( 21041247) Systolic blood pressure ( 30578418) Total cholesterol levels ( 30275531) Triiodothyronine levels ( 30824882) Two-hour glucose in pregnancy (gestational week 30-32) ( 30324795) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683) Weight ( 28552196) White blood cell count ( 32888494)	Barrett's esophagus or Esophageal adenocarcinoma ( 27527254) Glaucoma ( 30054594) Gout ( 22179738) Response to methotrexate in juvenile idiopathic arthritis ( 24709693) Response to platinum-based chemotherapy in non-small-cell lung cancer ( 22872573) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		59 interacting genes: ACTA1 ACTC1 ADAP1 AFAP1 AKAP9 ATF2 BRAF BTK CFTR CHAT CNN1 COPB1 COPB2 DSP EGFR ELAVL1 FYN GAD1 GAD2 GJA1 GNA12 GNA13 GRIN1 GRIN2D GRM5 H1-1 HK2 IKBKB ITGB1 ITGB2 KRT1 KRT18 MAP4K4 MAPK1 MAPK3 MAPT MARK2 MYH2 NANOG NUMB OPRD1 PDLIM5 PDPK1 PECAM1 PIK3CB PPP1R14A PRKD1 RACK1 RAD9A RAF1 RASGRP3 RPS6KB2 SLC25A4 SLC4A3 SNCA SRC TIAM1 TRPV1 VDAC1	29 interacting genes: CANX CLCN3 DERL1 DNAJA1 DNAJC5 EZR GOPC HSP90AA1 MARCHF2 NHS PDZD3 PDZK1 PPP2R1B PRKAA1 PRKACA PRKAR2A PRKCA PRKCE PRKG1 RNF5 SLC4A7 SLC4A8 SLC9A3R1 SLC9A3R2 SLC9A6 SNAP23 STUB1 STX1A UBE2I
Entrez ID		5581	1080
HPRD ID		01500	03883
Ensembl ID		ENSG00000171132	ENSG00000001626
Uniprot IDs		L7RTI5 Q02156	A0A024R730 P13569
PDB IDs		2WH0 5LIH	1NBD 1XMI 1XMJ 2BBO 2BBS 2BBT 2LOB 2PZE 2PZF 2PZG 3GD7 3ISW 4WZ6 5D2D 5D3E 5D3F 5TF7 5TF8 5TFA 5TFB 5TFC 5TFD 5TFF 5TFG 5TFI 5TFJ 5TGK 5UAK 6GJQ 6GJS 6GJU 6GK4 6GKD 6HEP 6MSM 6O1V 6O2P 6UK1
Enriched GO Terms of Interacting Partners?
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