PRKAR1B and PPP1R9A

Data Source:
HPRD (in vitro, in vivo)

		PRKAR1B	PPP1R9A
Description		protein kinase cAMP-dependent type I regulatory subunit beta	protein phosphatase 1 regulatory subunit 9A
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GO Annotations	Cellular Component	Multivesicular Body Cytosol Plasma Membrane CAMP-dependent Protein Kinase Complex Ciliary Base Schaffer Collateral - CA1 Synapse Hippocampal Mossy Fiber To CA3 Synapse Glutamatergic Synapse	Cytoplasm Cytosol Postsynaptic Density Actin Cytoskeleton Filopodium Dendrite Cortical Actin Cytoskeleton Neuromuscular Junction Neuronal Cell Body Dendritic Spine Neck Postsynaptic Actin Cytoskeleton Glutamatergic Synapse Growth Cone Lamellipodium
	Molecular Function	CAMP-dependent Protein Kinase Inhibitor Activity Protein Binding CAMP-dependent Protein Kinase Regulator Activity CAMP Binding Protein Kinase A Catalytic Subunit Binding	Protein Binding Protein C-terminus Binding Protein Phosphatase 1 Binding Protein Kinase Binding Protein Domain Specific Binding Identical Protein Binding Ion Channel Binding Actin Filament Binding GTPase Binding
	Biological Process	Renal Water Homeostasis Protein Phosphorylation Blood Coagulation Learning Or Memory Regulation Of Protein Kinase A Signaling Activation Of Protein Kinase A Activity Regulation Of CAMP-mediated Signaling Modulation Of Chemical Synaptic Transmission Cellular Response To Glucagon Stimulus Regulation Of Synaptic Vesicle Cycle Negative Regulation Of CAMP-dependent Protein Kinase Activity	Actin Filament Organization Aging Positive Regulation Of Neuron Projection Development Calcium-mediated Signaling Regulation Of Actin Filament Polymerization Neuron Projection Development Positive Regulation Of Protein Kinase Activity Regulation Of Filopodium Assembly Negative Regulation Of Stress Fiber Assembly Regulation Of Synapse Structural Plasticity Regulation Of Synapse Assembly Excitatory Postsynaptic Potential Positive Regulation Of Dendritic Spine Development Regulation Of Dendritic Spine Morphogenesis Cellular Response To Toxic Substance Postsynaptic Actin Cytoskeleton Organization Negative Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Long-term Synaptic Depression Negative Regulation Of Spontaneous Neurotransmitter Secretion
Pathways		PKA activation PKA activation in glucagon signalling DARPP-32 events Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Vasopressin regulates renal water homeostasis via Aquaporins CREB1 phosphorylation through the activation of Adenylate Cyclase Hedgehog 'off' state ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Body size at age 10 ( 32376654) Hematocrit ( 32888494 27863252) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Plasma free amino acid levels ( 30659259) Red blood cell count ( 32888494 27863252)	Glucocorticoid-induced osteonecrosis (age 10 years and older) ( 26265699) Waist circumference ( 28552196)
Interacting Genes		76 interacting genes: AKAP1 AKAP14 AKAP7 ANKS1A BAG3 BAG6 BOD1L2 CAMSAP1 CBX8 CCDC103 CCDC187 CDC37 CDKN1A CEP19 COX5B DACH1 DTNB EEF2KMT EGFR FAM161A FAM90A1 FCHSD2 GAS2L2 GLIS2 GNL3L GOLGA1 GPKOW GUCA1A IGFN1 INPP5J KANK2 KIF5B L3MBTL2 LENG1 LNX1 MBD3 MED8 MYO15B NTAQ1 NXF1 PIK3R3 POLE4 PPP1R9A PRKAA2 PRKACA PRKAR1A PRPF18 PSMG1 QRICH1 RARG RUNX1T1 SAP30BP SH2D4A SHC3 SMAD3 SMAD4 SMG9 SNW1 STK16 SYTL4 TASOR2 TEAD4 THRA TSGA10IP UACA VEZF1 WNK1 WRN ZBTB16 ZMYND19 ZNF177 ZNF329 ZNF35 ZNF410 ZNF559-ZNF177 ZNF76	10 interacting genes: ACTG1 PPP1CA PPP1CB PPP1CC PPP1R2 PPP1R9B PRKAR1B RPS6KA1 RPS6KB1 TGOLN2
Entrez ID		5575	55607
HPRD ID		01485	16000
Ensembl ID		ENSG00000188191	ENSG00000158528
Uniprot IDs		P31321	A4D1I0 B7ZLX4 Q9ULJ8
PDB IDs		4DIN 4F9K	1WF8
Enriched GO Terms of Interacting Partners?
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