ENAH and FAT1

Data Source:
HPRD (in vitro)

		ENAH	FAT1
Description		ENAH actin regulator	FAT atypical cadherin 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Lamellipodium Cell Junction Filopodium Synapse	Nucleus Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Focal Adhesion Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Actin Binding Protein Binding Profilin Binding SH3 Domain Binding WW Domain Binding	Calcium Ion Binding Protein Binding
	Biological Process	Axon Guidance Actin Polymerization Or Depolymerization Actin Polymerization-dependent Cell Motility	Actin Filament Organization Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Establishment Or Maintenance Of Cell Polarity Cell-cell Signaling Anatomical Structure Morphogenesis Cell Migration Cell-cell Adhesion
Pathways		Generation of second messenger molecules Signaling by ROBO receptors Signaling by ROBO receptors
Drugs
Diseases
GWAS		Delirium ( 29631748) Depression in smokers ( 30219690) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Neuroticism ( 27067015) Obesity-related traits ( 23251661)	Alzheimer disease and age of onset ( 26830138) Carotid plaque burden ( 28282560) Chronotype ( 26955885) Heel bone mineral density ( 30598549) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Macular thickness ( 30535121) Major depressive disorder ( 29317602) Medication use (calcium channel blockers) ( 31015401) Morning vs. evening chronotype ( 26955885) Obesity ( 21552555) PR interval ( 30046033 32439900) Urinary albumin-to-creatinine ratio ( 31630189)
Interacting Genes		27 interacting genes: ABI1 ABI2 ABI3 ABL1 APBB1 BAIAP2 DNMBP EVL FAT1 FYB1 GPHN HMGB1 KLHDC3 MAPK1 PFN1 PRPF40A RAC1 RAD51 ROBO4 SPTA1 TERF2IP TES VASP WAS XIRP1 YAP1 ZYX	12 interacting genes: CLK1 ENAH HOMER1 HOMER3 IGLL1 MT-ND1 NOXA1 SORBS2 TRAF4 TRIM14 UBC VASP
Entrez ID		55740	2195
HPRD ID		12360	02986
Ensembl ID		ENSG00000154380	ENSG00000083857
Uniprot IDs		A0A4D6J698 Q8N8S7	Q14517
PDB IDs		2HO2 2IYB 2XQN 4MY6 5N91 5N9C 5N9P 5NAJ 5NBF 5NBX 5NC2 5NC7 5NCF 5NCG 5NCP 5ND0 5NDU 5NEG 6RCF 6RCJ 6RD2 6XVT 6XXR 7A5M
Enriched GO Terms of Interacting Partners?
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