FAT1 and VASP

Data Source:
BioGRID (pull down)

		FAT1	VASP
Description		FAT atypical cadherin 1	vasodilator stimulated phosphoprotein
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Focal Adhesion Perinuclear Region Of Cytoplasm Extracellular Exosome	Cytosol Plasma Membrane Bicellular Tight Junction Focal Adhesion Actin Cytoskeleton Lamellipodium Membrane Filopodium Membrane Extracellular Exosome
	Molecular Function	Calcium Ion Binding Protein Binding	Actin Binding Protein Binding Profilin Binding SH3 Domain Binding Cadherin Binding
	Biological Process	Actin Filament Organization Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Establishment Or Maintenance Of Cell Polarity Cell-cell Signaling Anatomical Structure Morphogenesis Cell Migration Cell-cell Adhesion	Neural Tube Closure Axon Guidance Actin Polymerization Or Depolymerization Actin Cytoskeleton Organization Positive Regulation Of Actin Filament Polymerization Cell Junction Assembly Protein Homotetramerization
Pathways			Generation of second messenger molecules Signaling by ROBO receptors Signaling by ROBO receptors Cell-extracellular matrix interactions
Drugs
Diseases
GWAS		Alzheimer disease and age of onset ( 26830138) Carotid plaque burden ( 28282560) Chronotype ( 26955885) Heel bone mineral density ( 30598549) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Macular thickness ( 30535121) Major depressive disorder ( 29317602) Medication use (calcium channel blockers) ( 31015401) Morning vs. evening chronotype ( 26955885) Obesity ( 21552555) PR interval ( 30046033 32439900) Urinary albumin-to-creatinine ratio ( 31630189)	Alzheimer's disease or HDL levels (pleiotropy) ( 30805717)
Interacting Genes		12 interacting genes: CLK1 ENAH HOMER1 HOMER3 IGLL1 MT-ND1 NOXA1 SORBS2 TRAF4 TRIM14 UBC VASP	44 interacting genes: ABI1 ABI2 ABI3 ACTA1 ACTG1 APBB1 APBB1IP CDC42 CEP43 DMRTB1 DNMBP ENAH ERMAP EVL FAT1 FRS3 FYB1 GSN IQGAP1 LPP NOL3 NR4A1 PFN1 PFN2 PLSCR1 PRKACA PRKG1 PRPF40A PSORS1C2 RAD51 RAPH1 SAT1 SCGB2A2 SPTA1 TES TRIM15 TRIM9 VCL WAS WASL WWP2 XIRP1 XPO6 ZYX
Entrez ID		2195	7408
HPRD ID		02986	03415
Ensembl ID		ENSG00000083857	ENSG00000125753
Uniprot IDs		Q14517	A0A024R0V4 P50552
PDB IDs			1EGX 1JNG 1USD 1USE 2PAV 2PBD 3CHW
Enriched GO Terms of Interacting Partners?
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