PRKAG1 and KCNN4

Data Source:
HPRD (in vivo, two hybrid)

		PRKAG1	KCNN4
Description		protein kinase AMP-activated non-catalytic subunit gamma 1	potassium calcium-activated channel subfamily N member 4
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Membrane Nucleotide-activated Protein Kinase Complex	Plasma Membrane Voltage-gated Potassium Channel Complex Vesicle Neuron Projection Neuronal Cell Body
	Molecular Function	Protein Kinase Activity CAMP-dependent Protein Kinase Activity Protein Binding ATP Binding CAMP-dependent Protein Kinase Regulator Activity AMP Binding Protein Kinase Regulator Activity Protein Kinase Binding ADP Binding	Potassium Channel Activity Protein Binding Calmodulin Binding Calcium-activated Potassium Channel Activity Small Conductance Calcium-activated Potassium Channel Activity Protein Phosphatase Binding Intermediate Conductance Calcium-activated Potassium Channel Activity
	Biological Process	Regulation Of Glycolytic Process Protein Phosphorylation Fatty Acid Biosynthetic Process Cell Cycle Arrest Signal Transduction Spermatogenesis Positive Regulation Of Gene Expression Macroautophagy Regulation Of Macroautophagy Cellular Response To Glucose Starvation Positive Regulation Of Protein Kinase Activity Regulation Of Catalytic Activity Import Into Nucleus Regulation Of Signal Transduction By P53 Class Mediator Regulation Of CAMP-dependent Protein Kinase Activity	Immune System Process Ion Transport Potassium Ion Transport Calcium Ion Transport Cell Volume Homeostasis Defense Response Stabilization Of Membrane Potential Phospholipid Translocation Saliva Secretion Positive Regulation Of Protein Secretion Positive Regulation Of T Cell Receptor Signaling Pathway Potassium Ion Transmembrane Transport
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Macroautophagy Activation of PPARGC1A (PGC-1alpha) by phosphorylation Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of TP53 Activity through Phosphorylation Lipophagy Activation of AMPK downstream of NMDARs	Ca2+ activated K+ channels
Drugs		Adenosine phosphate Acetylsalicylic acid Fostamatinib	Clotrimazole Quinine Procaine Miconazole Halothane Trimebutine
Diseases
GWAS		Adult body size ( 32376654) Bipolar disorder ( 31043756) Body mass index ( 29273807) HDL cholesterol ( 30275531) Pulse pressure ( 27618447) Red cell distribution width ( 32888494) Systolic blood pressure ( 27618447 30578418)	Breast cancer ( 23535729) Granulocyte percentage of myeloid white cells ( 27863252) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Mean corpuscular hemoglobin concentration ( 29403010 32888494 27863252) Mean corpuscular volume ( 29403010 32888494 27863252) Mean platelet volume ( 32888494) Monocyte count ( 27863252) Monocyte percentage of white cells ( 32888494 27863252) Neutrophil percentage of white cells ( 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 32888494) Red blood cell count ( 32888494) Reticulocyte count ( 32888494) White blood cell count ( 32888494)
Interacting Genes		28 interacting genes: ACACA AP1S3 C1orf94 CBS EIF3G KCNN4 KEAP1 KRTAP1-1 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP4-12 KRTAP4-2 KRTAP9-2 KRTAP9-8 MEOX1 MEOX2 PAICS PAX6 PLEKHF2 PRKAA1 PRKAA2 PRKAB1 PRKAB2 PRKAG2 TEKT1 TNFAIP1	9 interacting genes: BIK CALM1 CNIH3 FXYD3 GPR152 PMP22 PRKAG1 SLC30A2 STX1B
Entrez ID		5571	3783
HPRD ID		04118	04130
Ensembl ID		ENSG00000181929	ENSG00000104783
Uniprot IDs		A0A024R125 P54619	O15554
PDB IDs		2UV4 2UV5 2UV6 2UV7 4CFE 4CFF 4RER 4REW 4ZHX 5EZV 5ISO 6B1U 6B2E 6C9F 6C9G 6C9H 6C9J	6CNM 6CNN 6CNO 6D42
Enriched GO Terms of Interacting Partners?
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