LIMS2 and HIPK3

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		LIMS2	HIPK3
Description		LIM zinc finger domain containing 2	homeodomain interacting protein kinase 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Focal Adhesion	Nucleus Cytoplasm Cytosol Plasma Membrane Nuclear Body PML Body
	Molecular Function	Metal Ion Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity ATP Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Cell Junction Assembly Negative Regulation Of Apoptotic Process Cell-cell Junction Organization Cell-cell Adhesion Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Neural Precursor Cell Proliferation Negative Regulation Of Hepatocyte Proliferation Positive Regulation Of Integrin-mediated Signaling Pathway	Protein Phosphorylation Apoptotic Process MRNA Transcription Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Peptidyl-tyrosine Phosphorylation Negative Regulation Of Apoptotic Process Negative Regulation Of JUN Kinase Activity
Pathways		Cell-extracellular matrix interactions
Drugs			Fostamatinib
Diseases
GWAS		Alzheimer's disease (cognitive decline) ( 23535033) Type 2 diabetes ( 25483131)	Anger ( 24489884) Obese vs. thin ( 30677029) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		17 interacting genes: APP CALCOCO2 GOLGA2 HIPK3 HRH1 ILK KRT40 KRTAP10-3 KRTAP10-5 KRTAP10-7 LMNA MDFI MTUS2 NOTCH2NLA RCHY1 TRIM55 TRIM63	37 interacting genes: AR ARRB2 C1QA CREB1 CREBBP DAXX FADD FAS FLNC GLUL GORASP1 GRB2 HEYL HNRNPA1 HNRNPA2B1 HNRNPH1 LIMD1 LIMK2 LIMS2 MBD1 MTMR4 NR2F2 RGS3 SIAH1 SIAH2 SKIL SNIP1 SRSF1 SRSF5 SUMO1 TGFB1I1 TOX4 TP73 TRA2B UBE2I ZNF107 ZYX
Entrez ID		55679	10114
HPRD ID		06389	05111
Ensembl ID		ENSG00000072163	ENSG00000110422
Uniprot IDs		A0A024RAH1 B3KNZ3 Q7Z4I7	A8KAE4 Q9H422
PDB IDs		3IXE
Enriched GO Terms of Interacting Partners?
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