HIPK3 and GLUL

Data Source:
BioGRID (two hybrid)

		HIPK3	GLUL
Description		homeodomain interacting protein kinase 3	glutamate-ammonia ligase
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Nuclear Body PML Body	Nucleus Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol Plasma Membrane Extracellular Exosome
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity ATP Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	Glutamate-ammonia Ligase Activity Protein Binding ATP Binding Protein-cysteine S-palmitoyltransferase Activity Identical Protein Binding Metal Ion Binding
	Biological Process	Protein Phosphorylation Apoptotic Process MRNA Transcription Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Peptidyl-tyrosine Phosphorylation Negative Regulation Of Apoptotic Process Negative Regulation Of JUN Kinase Activity	Neurotransmitter Uptake Angiogenesis Glutamate Catabolic Process Glutamine Biosynthetic Process Cell Population Proliferation Cellular Amino Acid Biosynthetic Process Regulation Of Endothelial Cell Migration Protein Phosphopantetheinylation Protein Palmitoylation Ribosome Biogenesis Regulation Of Sprouting Angiogenesis Regulation Of Protein Localization To Nucleolus
Pathways			Astrocytic Glutamate-Glutamine Uptake And Metabolism Glutamate and glutamine metabolism
Drugs		Fostamatinib	L-Glutamine Glutamic acid
Diseases			Congenital systemic glutamine deficiency (CSGD); Glutamine synthetase deficiency
GWAS		Anger ( 24489884) Obese vs. thin ( 30677029) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Cardiovascular heart disease in diabetics ( 23982368) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) HDL cholesterol levels ( 32203549) Morning person ( 30696823)
Interacting Genes		37 interacting genes: AR ARRB2 C1QA CREB1 CREBBP DAXX FADD FAS FLNC GLUL GORASP1 GRB2 HEYL HNRNPA1 HNRNPA2B1 HNRNPH1 LIMD1 LIMK2 LIMS2 MBD1 MTMR4 NR2F2 RGS3 SIAH1 SIAH2 SKIL SNIP1 SRSF1 SRSF5 SUMO1 TGFB1I1 TOX4 TP73 TRA2B UBE2I ZNF107 ZYX	22 interacting genes: CASP8AP2 CRBN CYP39A1 DYNLL1 EP300 HIPK1 HIPK3 HSD17B10 HTR2A MT-ND5 NFKB1 NUDT18 PIAS1 PIAS2 PIAS3 PLEKHF2 PPARD RABEPK RBBP6 SKIL TAT UBE2I
Entrez ID		10114	2752
HPRD ID		05111	00701
Ensembl ID		ENSG00000110422	ENSG00000135821
Uniprot IDs		A8KAE4 Q9H422	A8YXX4 P15104
PDB IDs			2OJW 2QC8
Enriched GO Terms of Interacting Partners?
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