HIPK3 and HEYL

Data Source:
HPRD (two hybrid)

		HIPK3	HEYL
Description		homeodomain interacting protein kinase 3	hes related family bHLH transcription factor with YRPW motif like
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Nuclear Body PML Body	Chromatin Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity ATP Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Protein Homodimerization Activity AF-1 Domain Binding
	Biological Process	Protein Phosphorylation Apoptotic Process MRNA Transcription Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Peptidyl-tyrosine Phosphorylation Negative Regulation Of Apoptotic Process Negative Regulation Of JUN Kinase Activity	Negative Regulation Of Transcription By RNA Polymerase II Outflow Tract Morphogenesis Aortic Valve Morphogenesis Atrioventricular Valve Morphogenesis Pulmonary Valve Morphogenesis Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Endocardial Cushion Morphogenesis Cardiac Ventricle Morphogenesis Regulation Of Transcription By RNA Polymerase II Notch Signaling Pathway Positive Regulation Of Transcription Of Notch Receptor Target Anterior/posterior Pattern Specification Mesenchymal Cell Development Glomerulus Development Skeletal Muscle Cell Differentiation Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Neuron Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Neurogenesis Cardiac Epithelial To Mesenchymal Transition Ventricular Septum Morphogenesis Negative Regulation Of Androgen Receptor Signaling Pathway Notch Signaling Involved In Heart Development Cellular Response To BMP Stimulus Proximal Tubule Development
Pathways			NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH3 Intracellular Domain Regulates Transcription
Drugs		Fostamatinib
Diseases
GWAS		Anger ( 24489884) Obese vs. thin ( 30677029) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	HDL cholesterol levels ( 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Red blood cell traits ( 23222517) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)
Interacting Genes		37 interacting genes: AR ARRB2 C1QA CREB1 CREBBP DAXX FADD FAS FLNC GLUL GORASP1 GRB2 HEYL HNRNPA1 HNRNPA2B1 HNRNPH1 LIMD1 LIMK2 LIMS2 MBD1 MTMR4 NR2F2 RGS3 SIAH1 SIAH2 SKIL SNIP1 SRSF1 SRSF5 SUMO1 TGFB1I1 TOX4 TP73 TRA2B UBE2I ZNF107 ZYX	21 interacting genes: APP ATF7IP ATXN1 BANP HAND1 HAND2 HIPK3 HTT KRTAP6-2 LAPTM5 MDFI PLEKHB2 PPP1CA RBPMS RPGRIP1 SKIL SMAD3 SMAD7 SMAD9 SP8 ZNF512B
Entrez ID		10114	26508
HPRD ID		05111	16419
Ensembl ID		ENSG00000110422	ENSG00000163909
Uniprot IDs		A8KAE4 Q9H422	Q9NQ87
PDB IDs
Enriched GO Terms of Interacting Partners?
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