NPLOC4 and VPS26B

Data Source:
BioGRID (two hybrid)

		NPLOC4	VPS26B
Description		NPL4 homolog, ubiquitin recognition factor	VPS26, retromer complex component B
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Endoplasmic Reticulum Cytosol VCP-NPL4-UFD1 AAA ATPase Complex UFD1-NPL4 Complex Nuclear Outer Membrane-endoplasmic Reticulum Membrane Network	Endosome Early Endosome Late Endosome Cytosol Retromer Complex Retromer, Cargo-selective Complex Phagocytic Vesicle
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding Ubiquitin Binding Metal Ion Binding	Protein Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Golgi Organization Ubiquitin-dependent ERAD Pathway Retrograde Protein Transport, ER To Cytosol Negative Regulation Of Type I Interferon Production Negative Regulation Of RIG-I Signaling Pathway Error-free Translesion Synthesis	Intracellular Protein Transport Regulation Of Macroautophagy Retrograde Transport, Endosome To Golgi Cellular Response To Interferon-gamma
Pathways		Translesion Synthesis by POLH
Drugs
Diseases
GWAS		Advanced age-related macular degeneration ( 26691988) Cataracts (operation) ( 31816047) Central corneal thickness ( 32528159) Eye color traits ( 20463881) Intraocular pressure ( 29617998) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Myopia ( 27182965) Non-albumin protein levels ( 29403010) Optic disc size ( 31809533) Red blood cell count ( 32888494 27863252) Red cell distribution width ( 32888494 27863252 28957414) Refractive astigmatism ( 30306274) Refractive error ( 32231278)	Verbal declarative memory ( 25648963)
Interacting Genes		8 interacting genes: CDC42 ERCC6 GZMK MAP3K1 RAF1 UBC UFD1 VPS26B	2 interacting genes: NPLOC4 VPS35
Entrez ID		55666	112936
HPRD ID		06975	14395
Ensembl ID		ENSG00000182446	ENSG00000151502
Uniprot IDs		A0A024R8R4 Q8TAT6	A0A024R3L9 Q4G0F5
PDB IDs
Enriched GO Terms of Interacting Partners?
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