LYAR and FGF18

Data Source:
BioGRID (two hybrid)

		LYAR	FGF18
Description		Ly1 antibody reactive	fibroblast growth factor 18
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GO Annotations	Cellular Component	Photoreceptor Outer Segment Nucleus Nucleoplasm Nucleolus Cytoplasm	Extracellular Region Extracellular Space Nucleolus Cytoplasm
	Molecular Function	DNA Binding RNA Binding Protein Binding Activating Transcription Factor Binding Identical Protein Binding Metal Ion Binding Transcription Regulator Inhibitor Activity	Fibroblast Growth Factor Receptor Binding Type 1 Fibroblast Growth Factor Receptor Binding Type 2 Fibroblast Growth Factor Receptor Binding Growth Factor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II RRNA Processing Innate Immune Response Negative Regulation Of Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase I Erythrocyte Development Positive Regulation Of Phagocytosis	MAPK Cascade Angiogenesis Positive Regulation Of Protein Phosphorylation Regulation Of Endothelial Cell Proliferation Intramembranous Ossification Endochondral Ossification Chondrocyte Development Signal Transduction Cell-cell Signaling Positive Regulation Of Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Anatomical Structure Morphogenesis Animal Organ Morphogenesis Positive Regulation Of Gene Expression Cell Differentiation Lung Development Regulation Of Cell Migration Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Chondrocyte Differentiation Positive Regulation Of MAP Kinase Activity Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Angiogenesis Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Sprouting Angiogenesis Positive Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor
Pathways			PI3K Cascade PIP3 activates AKT signaling Signaling by activated point mutants of FGFR3 FGFR4 ligand binding and activation FGFR3b ligand binding and activation FGFR3c ligand binding and activation FGFR2c ligand binding and activation FGFR3 mutant receptor activation Activated point mutants of FGFR2 Constitutive Signaling by Aberrant PI3K in Cancer Phospholipase C-mediated cascade; FGFR2 Phospholipase C-mediated cascade; FGFR3 Phospholipase C-mediated cascade; FGFR4 PI-3K cascade:FGFR2 SHC-mediated cascade:FGFR2 FRS-mediated FGFR2 signaling SHC-mediated cascade:FGFR3 FRS-mediated FGFR3 signaling PI-3K cascade:FGFR3 FRS-mediated FGFR4 signaling SHC-mediated cascade:FGFR4 PI-3K cascade:FGFR4 Negative regulation of FGFR2 signaling Negative regulation of FGFR3 signaling Negative regulation of FGFR4 signaling Signaling by FGFR2 in disease FGFRL1 modulation of FGFR1 signaling RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Signaling by FGFR3 point mutants in cancer
Drugs
Diseases
GWAS		Disease progression in age-related macular degeneration ( 29346644)	Brain morphology (MOSTest) ( 32665545) Chronic obstructive pulmonary disease ( 30804561) FEV1 ( 30804560) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Height ( 28552196 25282103 31562340) Lung function (FEV1/FVC) ( 30804560) Peak expiratory flow ( 30804560) PR interval ( 32439900) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		12 interacting genes: ADSS1 BEND7 CD2 FGF18 PHF20L1 PRKRA SDCBP2 SREK1IP1 TERF1 TERF2 ZBTB16 ZHX1	6 interacting genes: FGFR1 FGFR2 FGFR3 FGFR4 LYAR PTX3
Entrez ID		55646	8817
HPRD ID		10064	04766
Ensembl ID		ENSG00000145220	ENSG00000156427
Uniprot IDs		Q9NX58	O76093
PDB IDs		6ZMI 6ZMO 6ZVH	4CJM
Enriched GO Terms of Interacting Partners?
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