OTUB1 and PACS1

Data Source:
BioGRID (two hybrid)

		OTUB1	PACS1
Description		OTU deubiquitinase, ubiquitin aldehyde binding 1	phosphofurin acidic cluster sorting protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Extracellular Exosome	Golgi Apparatus Cytosol COPI-coated Vesicle
	Molecular Function	Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding NEDD8-specific Protease Activity Ubiquitin Protein Ligase Binding Ubiquitin Binding	Protein Binding Ion Channel Binding
	Biological Process	Adaptive Immune Response DNA Repair Cellular Response To DNA Damage Stimulus Protein Deubiquitination Protein Phosphopantetheinylation Protein K48-linked Deubiquitination Negative Regulation Of Histone H2A K63-linked Ubiquitination Negative Regulation Of Double-strand Break Repair	Protein Localization To Golgi Apparatus Regulation Of Defense Response To Virus By Virus Protein Localization To Plasma Membrane
Pathways		Ub-specific processing proteases Ovarian tumor domain proteases	Nef mediated downregulation of MHC class I complex cell surface expression
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756)	Acne (severe) ( 24927181) Bipolar disorder ( 21926972 31043756) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Electroencephalogram traits ( 25387704) Immature fraction of reticulocytes ( 32888494) Obesity (early onset extreme) ( 23563609) Serum uric acid levels ( 32514006)
Interacting Genes		55 interacting genes: ACVR1 ACVR1B ANXA1 ANXA7 AURKA BIRC2 BMPR1A BMPR1B CDKN1A CPEB2 CSNK2A1 ECT2 ESR1 FOXM1 H2AX IL1RL2 KDM1A MAPT NEDD8 PJA1 RFFL RHOA RNF126 RNF128 SLC7A11 SMAD2 SMAD3 SMAD4 SMAD9 SNAI1 TGFBR1 TP53 TRAF6 TRIM54 TRIM55 TRIM63 TSC22D1 TTR UBA6 UBC UBD UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E2 UBE2E3 UBE2N UBE2S UBE2V2 UBE2Z UBE4B USP15 USP21 USP28	10 interacting genes: CLCN7 CSNK2A1 FURIN GGA3 IGF2R JUN PKD2 PPP2CA PPP2CB VAMP4
Entrez ID		55611	55690
HPRD ID		08493	06320
Ensembl ID		ENSG00000167770	ENSG00000175115
Uniprot IDs		B3KUV5 Q96FW1	A0A024R5H6 Q6VY07
PDB IDs		2ZFY 3VON 4DDG 4DDI 4DHZ 4I6L 4LDT
Enriched GO Terms of Interacting Partners?
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