OTUB1 and FOXM1

Data Source:
BioGRID (enzymatic study)

		OTUB1	FOXM1
Description		OTU deubiquitinase, ubiquitin aldehyde binding 1	forkhead box M1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Extracellular Exosome	Chromatin Nucleus Nucleoplasm
	Molecular Function	Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding NEDD8-specific Protease Activity Ubiquitin Protein Ligase Binding Ubiquitin Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Protein Kinase Binding
	Biological Process	Adaptive Immune Response DNA Repair Cellular Response To DNA Damage Stimulus Protein Deubiquitination Protein Phosphopantetheinylation Protein K48-linked Deubiquitination Negative Regulation Of Histone H2A K63-linked Ubiquitination Negative Regulation Of Double-strand Break Repair	G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II DNA Repair Regulation Of Transcription By RNA Polymerase II DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Positive Regulation Of Cell Population Proliferation Negative Regulation Of Stress-activated MAPK Cascade Regulation Of Cell Population Proliferation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Ras Protein Signal Transduction Regulation Of Cell Cycle Regulation Of Cell Cycle Arrest Negative Regulation Of Cell Aging Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Double-strand Break Repair
Pathways		Ub-specific processing proteases Ovarian tumor domain proteases	Polo-like kinase mediated events Cyclin A/B1/B2 associated events during G2/M transition
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756)	Height ( 31562340)
Interacting Genes		55 interacting genes: ACVR1 ACVR1B ANXA1 ANXA7 AURKA BIRC2 BMPR1A BMPR1B CDKN1A CPEB2 CSNK2A1 ECT2 ESR1 FOXM1 H2AX IL1RL2 KDM1A MAPT NEDD8 PJA1 RFFL RHOA RNF126 RNF128 SLC7A11 SMAD2 SMAD3 SMAD4 SMAD9 SNAI1 TGFBR1 TP53 TRAF6 TRIM54 TRIM55 TRIM63 TSC22D1 TTR UBA6 UBC UBD UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E2 UBE2E3 UBE2N UBE2S UBE2V2 UBE2Z UBE4B USP15 USP21 USP28	18 interacting genes: BANP CCNE1 CDK1 CDK2 CDK4 CDK6 CHEK2 CREBBP DCAF1 OS9 OTUB1 SIRT1 STAT3 SUMO1 UBE2I UCHL3 USP21 ZBTB3
Entrez ID		55611	2305
HPRD ID		08493	03823
Ensembl ID		ENSG00000167770	ENSG00000111206
Uniprot IDs		B3KUV5 Q96FW1	A0A0D9SFF0 A0A2P9DTZ1 A0A2P9DTZ8 A8K591 Q08050 Q53Y49
PDB IDs		2ZFY 3VON 4DDG 4DDI 4DHZ 4I6L 4LDT	3G73
Enriched GO Terms of Interacting Partners?
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