OTUB1 and RNF128

Data Source:
BioGRID (pull down)

		OTUB1	RNF128
Description		OTU deubiquitinase, ubiquitin aldehyde binding 1	ring finger protein 128
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Extracellular Exosome	Cytoplasm Late Endosome Endoplasmic Reticulum Golgi Apparatus Cytosol Cytoskeleton Integral Component Of Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding NEDD8-specific Protease Activity Ubiquitin Protein Ligase Binding Ubiquitin Binding	Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Adaptive Immune Response DNA Repair Cellular Response To DNA Damage Stimulus Protein Deubiquitination Protein Phosphopantetheinylation Protein K48-linked Deubiquitination Negative Regulation Of Histone H2A K63-linked Ubiquitination Negative Regulation Of Double-strand Break Repair	Negative Regulation Of Cytokine Production Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein Deubiquitination Regulation Of Protein Stability Protein Localization To Lysosome Positive Regulation Of Protein Catabolic Process In The Vacuole
Pathways		Ub-specific processing proteases Ovarian tumor domain proteases	Ub-specific processing proteases Ovarian tumor domain proteases
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756)	Alcoholic chronic pancreatitis ( 28754779) Creatinine levels ( 31015462) Estimated glomerular filtration rate ( 31015462)
Interacting Genes		55 interacting genes: ACVR1 ACVR1B ANXA1 ANXA7 AURKA BIRC2 BMPR1A BMPR1B CDKN1A CPEB2 CSNK2A1 ECT2 ESR1 FOXM1 H2AX IL1RL2 KDM1A MAPT NEDD8 PJA1 RFFL RHOA RNF126 RNF128 SLC7A11 SMAD2 SMAD3 SMAD4 SMAD9 SNAI1 TGFBR1 TP53 TRAF6 TRIM54 TRIM55 TRIM63 TSC22D1 TTR UBA6 UBC UBD UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E2 UBE2E3 UBE2N UBE2S UBE2V2 UBE2Z UBE4B USP15 USP21 USP28	16 interacting genes: APPBP2 CD151 CD40LG CD81 CEP76 OTUB1 SNX17 TBK1 TP53 UBE2D1 UBE2E1 UBE2H UBE2I UBE2N UBE2T UBQLN2
Entrez ID		55611	79589
HPRD ID		08493	02340
Ensembl ID		ENSG00000167770	ENSG00000133135
Uniprot IDs		B3KUV5 Q96FW1	Q8TEB7
PDB IDs		2ZFY 3VON 4DDG 4DDI 4DHZ 4I6L 4LDT	3ICU
Enriched GO Terms of Interacting Partners?
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