PACS1 and GGA3

Data Source:
HPRD (in vitro, in vivo)

		PACS1	GGA3
Description		phosphofurin acidic cluster sorting protein 1	golgi associated, gamma adaptin ear containing, ARF binding protein 3
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus Cytosol COPI-coated Vesicle	Lysosome Golgi Apparatus Trans-Golgi Network Endosome Membrane Early Endosome Membrane Protein-containing Complex Recycling Endosome Membrane
	Molecular Function	Protein Binding Ion Channel Binding	Protein Binding Small GTPase Binding Ubiquitin Binding Protein-containing Complex Binding
	Biological Process	Protein Localization To Golgi Apparatus Regulation Of Defense Response To Virus By Virus Protein Localization To Plasma Membrane	Protein Targeting To Lysosome Intracellular Protein Transport Regulation Of Protein Stability Protein Destabilization Endocytic Recycling Protein Localization To Cell Surface Golgi To Plasma Membrane Protein Transport Cellular Protein Metabolic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of Amyloid-beta Formation
Pathways		Nef mediated downregulation of MHC class I complex cell surface expression	TBC/RABGAPs MET receptor recycling Amyloid fiber formation
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Bipolar disorder ( 21926972 31043756) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Electroencephalogram traits ( 25387704) Immature fraction of reticulocytes ( 32888494) Obesity (early onset extreme) ( 23563609) Serum uric acid levels ( 32514006)
Interacting Genes		10 interacting genes: CLCN7 CSNK2A1 FURIN GGA3 IGF2R JUN PKD2 PPP2CA PPP2CB VAMP4	38 interacting genes: ADRA2A ADRA2B AFTPH AP1S2 ARAP3 ARF1 ARF3 CDKN2A CLINT1 CLTC CYTH2 DAZAP2 EGFR GGA1 GGA2 IGF2R LITAF LRP10 M6PR P4HA3 PACS1 PLEKHB2 RABEP1 RNF11 RNF214 RPS27A STAB1 SYNRG TBC1D3 TOLLIP TRAPPC6A TRIM23 TSG101 UBC UPRT VPS11 VPS18 ZNF497
Entrez ID		55690	23163
HPRD ID		06320	10443
Ensembl ID		ENSG00000175115	ENSG00000125447
Uniprot IDs		A0A024R5H6 Q6VY07	A8K6M0 B7Z456 Q9NZ52
PDB IDs			1JPL 1JUQ 1LF8 1P4U 1WR6 1YD8
Enriched GO Terms of Interacting Partners?
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