VEZT and C5

Data Source:
BioGRID (two hybrid)

		VEZT	C5
Description		vezatin, adherens junctions transmembrane protein	complement C5
Image		No pdb structure
GO Annotations	Cellular Component	Acrosomal Vesicle Stereocilia Ankle Link Complex Nucleoplasm Cytosol Adherens Junction Integral Component Of Membrane Stereocilium Membrane	Extracellular Region Membrane Attack Complex Extracellular Space Extracellular Exosome
	Molecular Function	Myosin Binding	Endopeptidase Inhibitor Activity Signaling Receptor Binding Protein Binding Chemokine Activity
	Biological Process	Cell-cell Adhesion	Activation Of MAPK Activity In Utero Embryonic Development Chemotaxis Inflammatory Response Complement Activation, Alternative Pathway Complement Activation, Classical Pathway Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Macrophage Chemotaxis Negative Regulation Of Endopeptidase Activity Cytolysis Regulation Of Complement Activation Positive Regulation Of Chemokine Production Positive Regulation Of Angiogenesis Cell Chemotaxis
Pathways			Terminal pathway of complement Activation of C3 and C5 Peptide ligand-binding receptors G alpha (i) signalling events Regulation of Complement cascade
Drugs			Human immunoglobulin G Eculizumab Zinc Copper Ravulizumab Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases			Late complement pathway defects, including the following seven diseases: C5 deficiency; C6 deficiency; C7 deficiency; C8 alpha-chain deficiency; C8 beta-chain deficiency; C8 gamma-chain deficiency; C9 deficiency
GWAS		Brain morphology (MOSTest) ( 32665545) Endometriosis ( 23104006 23472165 28537267) Pursuit maintenance gain ( 29064472)	Blood protein levels ( 30072576) Coronary artery disease ( 29212778) Hip circumference adjusted for BMI ( 25673412) Pulse pressure ( 27841878) Refractive error ( 32231278) Rheumatoid arthritis ( 30891314 24390342 20453842 19503088)
Interacting Genes		16 interacting genes: ANKS6 AQP6 C5 CMTM3 CREB3L1 GORAB HSD17B11 LRRC4C MTIF3 MYO7A PGRMC2 RMDN2 SACM1L TLCD4 TMEM201 TSNARE1	22 interacting genes: ANKS6 AQP6 C2 C3 C5AR1 C6 C7 C8B CPB2 CPLX4 CPN1 CREB3L1 EBP KEL KIR3DL3 LMNA MMGT1 NEMP1 PGRMC2 POU6F2 SSMEM1 VEZT
Entrez ID		55591	727
HPRD ID		11671	00405
Ensembl ID		ENSG00000028203	ENSG00000106804
Uniprot IDs		Q9HBM0	P01031 Q59GS8
PDB IDs			1CFA 1KJS 1XWE 3CU7 3HQA 3HQB 3KLS 3KM9 3PRX 3PVM 4A5W 4E0S 4P39 4UU9 5B4P 5B71 5HCC 5HCD 5HCE 5I5K 6H03 6H04 6RPT
Enriched GO Terms of Interacting Partners?
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