NAGK and CEP43

Data Source:
BioGRID (two hybrid)

		NAGK	CEP43
Description		N-acetylglucosamine kinase	centrosomal protein 43
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GO Annotations	Cellular Component	Cytosol Extracellular Exosome	Nucleus Centrosome Centriole Cytosol Cell Projection Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding ATP Binding N-acetylglucosamine Kinase Activity	Protein Binding Protein Kinase Binding Protein Tyrosine Kinase Inhibitor Activity Protein Homodimerization Activity
	Biological Process	N-acetylglucosamine Metabolic Process UDP-N-acetylglucosamine Biosynthetic Process N-acetylmannosamine Metabolic Process N-acetylneuraminate Catabolic Process Carbohydrate Phosphorylation	G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Protein Kinase Activity Positive Regulation Of Cell Population Proliferation Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Microtubule Anchoring Negative Regulation Of Protein Tyrosine Kinase Activity Ciliary Basal Body-plasma Membrane Docking
Pathways		Synthesis of UDP-N-acetyl-glucosamine	Signaling by cytosolic FGFR1 fusion mutants Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane Signaling by FGFR1 in disease AURKA Activation by TPX2
Drugs		N-Acetylglucosamine
Diseases
GWAS		Blood protein levels ( 30072576 29875488 28240269) Erythema nodosum in inflammatory bowel disease ( 24487271)
Interacting Genes		33 interacting genes: ACTR10 ANKRD1 CCDC158 CDKN2C CEP43 DACH1 DCP2 DYNC1I1 GNPNAT1 LACTB2 LENG1 LMO1 LNX1 LNX2 LSM8 MEOX1 MTHFD2 NTAQ1 PJA1 PKM PPHLN1 REL SDCBP SF3B3 SMAD2 SMAD9 SPRED1 SRPK2 STK16 SYNE4 TCF12 TNNT1 WDR82	5 interacting genes: CEP19 NAGK PPP2R1B S100A6 VASP
Entrez ID		55577	11116
HPRD ID		08441	10392
Ensembl ID		ENSG00000124357	ENSG00000213066
Uniprot IDs		A0A384N6G7 C9JEV6 Q9UJ70	A0A087WV25 B4DH64 O95684
PDB IDs		2CH5 2CH6	2D68
Enriched GO Terms of Interacting Partners?
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