CDC16 and HINT1

Data Source:
BioGRID (two hybrid)

		CDC16	HINT1
Description		cell division cycle 16	histidine triad nucleotide binding protein 1
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GO Annotations	Cellular Component	Nucleoplasm Anaphase-promoting Complex Cytoplasm Centrosome Cytosol Mitotic Spindle	Histone Deacetylase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Plasma Membrane Extracellular Exosome
	Molecular Function	Protein Binding	Nucleotide Binding Protein Kinase C Binding Protein Binding Hydrolase Activity Adenosine 5'-monophosphoramidase Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Metaphase/anaphase Transition Of Mitotic Cell Cycle Protein Ubiquitination Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Mitotic Metaphase/anaphase Transition Cell Division Protein K11-linked Ubiquitination Regulation Of Mitotic Cell Cycle Phase Transition	Regulation Of Transcription, DNA-templated Signal Transduction Purine Ribonucleotide Catabolic Process Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Pathways		Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation
Drugs			Adenosine phosphate Guanosine-5'-Monophosphate 5'-O-(N-Ethyl-Sulfamoyl)Adenosine Adenosine-5'-ditungstate 8-Bromo-Adenosine-5'-Monophosphate
Diseases
GWAS		Metabolite levels ( 23823483) Monocyte percentage of white cells ( 32888494) Prudent dietary pattern ( 28644415) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878 30578418)	Blood protein levels ( 29875488) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)
Interacting Genes		24 interacting genes: ANAPC10 ANAPC11 ANAPC7 BUB1B C11orf49 CDC20 CDC23 CDC26 CDC27 DAB2 DNAJA1 FBXO5 FTH1 HINT1 LINC00839 MAD2L1 MAPK9 MTNR1B PPP5C SKIL SMAD2 SMAD3 UBE2S XRCC5	6 interacting genes: CDC16 CPSF7 ERBB3 MITF SP1 TRIM29
Entrez ID		8881	3094
HPRD ID		04587	03204
Ensembl ID		ENSG00000130177	ENSG00000169567
Uniprot IDs		A0A024RDZ2 A0A3B3ISD2 B2RCW0 Q13042	A0A384NPU2 P49773
PDB IDs		3HYM 4UI9 5A31 5G04 5G05 5KHR 5KHU 5L9T 5L9U 5LCW 6Q6G 6Q6H 6TLJ 6TM5	1AV5 1KPA 1KPB 1KPC 1KPE 1KPF 3TW2 4EQE 4EQG 4EQH 4ZKL 4ZKV 5ED3 5ED6 5EMT 5I2E 5I2F 5IPB 5IPC 5IPD 5IPE 5KLY 5KLZ 5KM0 5KM1 5KM2 5KM3 5KM4 5KM6 5KMA 5KMB 5KMC 5O8I 5WA8 5WA9 5WAA 6B42 6G9Z 6J53 6J58 6J5S 6J5Z 6J64 6J65 6N3V 6N3W 6N3X 6N3Y 6YQM
Enriched GO Terms of Interacting Partners?
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