PPP2R5A and DAPK1

Data Source:
BioGRID (enzymatic study)

		PPP2R5A	DAPK1
Description		protein phosphatase 2 regulatory subunit B'alpha	death associated protein kinase 1
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GO Annotations	Cellular Component	Protein Phosphatase Type 2A Complex Chromosome, Centromeric Region Nucleus Cytoplasm Centrosome Cytosol Membrane Z Disc M Band	Nucleus Cytoplasm Plasma Membrane Actin Cytoskeleton
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Binding Protein Phosphatase Regulator Activity Kinase Binding Protein Phosphatase Activator Activity	Protein Kinase Activity Protein Serine/threonine Kinase Activity Calmodulin-dependent Protein Kinase Activity Protein Binding Calmodulin Binding ATP Binding GTP Binding Syntaxin-1 Binding Identical Protein Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Protein Dephosphorylation Signal Transduction Regulation Of Protein Autophosphorylation Positive Regulation Of Protein Dephosphorylation Regulation Of Phosphoprotein Phosphatase Activity Negative Regulation Of Lipid Kinase Activity Negative Regulation Of Protein Localization To Plasma Membrane	Protein Phosphorylation Apoptotic Process Regulation Of Autophagy Positive Regulation Of Autophagy Negative Regulation Of Translation Intracellular Signal Transduction Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Protein Autophosphorylation Cellular Response To Interferon-gamma Cellular Response To Hydroperoxide Apoptotic Signaling Pathway Regulation Of NMDA Receptor Activity
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion CTLA4 inhibitory signaling Platelet sensitization by LDL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Signaling by GSK3beta mutants S33 mutants of beta-catenin aren't phosphorylated S37 mutants of beta-catenin aren't phosphorylated S45 mutants of beta-catenin aren't phosphorylated T41 mutants of beta-catenin aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex RHO GTPases Activate Formins RAF activation Negative regulation of MAPK pathway PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Caspase activation via Dependence Receptors in the absence of ligand
Drugs			5,6-Dihydro-Benzo[H]Cinnolin-3-Ylamine Phosphoaminophosphonic Acid-Adenylate Ester 6-(3-AMINOPROPYL)-4,9-DIMETHYLPYRROLO[3,4-C]CARBAZOLE-1,3(2H,6H)-DIONE Fostamatinib
Diseases			Bladder cancer
GWAS		Deep white matter hyperintensities ( 32517579) HDL cholesterol levels ( 32203549) Nickel levels ( 26025379)	Blood pressure ( 24954895) Cognitive function ( 24684796) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Height ( 31562340) Immune reponse to smallpox (secreted IFN-alpha) ( 22610502) Night sleep phenotypes ( 27126917) Ovarian cancer ( 30557369) Post bronchodilator FEV1/FVC ratio ( 26634245) Response to gemcitabine in pancreatic cancer ( 22293537)
Interacting Genes		27 interacting genes: APC AXIN2 BCL2 BEST1 C1orf21 CHEK2 CSNK1A1 CTLA4 DAPK1 DZIP1 EIF2AK2 ERICH4 GNL3 JAK2 MAPT MOS NEK1 NOS3 PPFIA1 PPP2R1A PTTG1 SGO1 SHC1 SHFL TNNT2 TP63 USHBP1	107 interacting genes: ABL1 ABLIM1 AHDC1 APEX2 ARRDC1 ARRDC1-AS1 ATF6 BAG2 BAIAP2 C11orf65 CALM1 CAPRIN1 CBLB CCDC149 CDC42EP3 CDC42SE1 CMTM4 CNTROB DENND1C DTWD1 DUS1L DUX3 EPHA1 FADD FAM107A FAM126B FBXL14 FBXW11 FIBP GASK1B GTF2F1 IKBKG JHY LIMA1 LIMS1 LINC02875 LMF2 LNX1 LOXL2 MAPK1 MAPK3 MCM10 MDM2 MIB1 MRGBP MTHFD2 MYL12B NCBP3 NECAB1 NECAP1 NR3C1 ORMDL2 PAK6 PAPSS2 PCP4 PHKG2 PIM1 PIM2 POLR2M PPP1R14A PPP2R1A PPP2R2D PPP2R5A PRKAG2 PRR16 PWP1 RAPGEF3 RASGRP2 RCHY1 RFC5 RHBDD1 RPAP3 RPL41 SARNP SCEL SCRN3 SCYL1 SGK2 SH2D2A SLAIN2 SNRPA SNURF SNX9 SPATS2 SPRR2G SRSF10 STARD3 STUB1 STX1A TAS2R60 TBC1D22B TNFRSF1A TPD52L1 TRADD TRAPPC2 TTC27 TUBB4B UNC5A UNC5B UNC5C VGLL4 VN1R1 WWTR1 YWHAB ZAP70 ZMAT4 ZMYM5
Entrez ID		5525	1612
HPRD ID		03384	02902
Ensembl ID		ENSG00000066027	ENSG00000196730
Uniprot IDs		Q15172	B4DHI4 P53355 Q59H88
PDB IDs		6NTS	1IG1 1JKK 1JKL 1JKS 1JKT 1P4F 1WVW 1WVX 1WVY 1YR5 2W4J 2W4K 2X0G 2XUU 2XZS 2Y0A 2Y4P 2Y4V 2YAK 3DFC 3DGK 3EH9 3EHA 3F5G 3F5U 3GU4 3GU5 3GU6 3GU7 3GU8 3GUB 3ZXT 4B4L 4PF4 4TL0 4TXC 4UV0 4YO4 4YPD 5AUT 5AUU 5AUV 5AUW 5AUX 5AUY 5AUZ 5AV0 5AV1 5AV2 5AV3 5AV4 6AAR 6FHA 6FHB 6GY5 6IN4 6QMO 6QN4
Enriched GO Terms of Interacting Partners?
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