PPP2R5A and TNNT2

Data Source:
BioGRID (two hybrid)

		PPP2R5A	TNNT2
Description		protein phosphatase 2 regulatory subunit B'alpha	troponin T2, cardiac type
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GO Annotations	Cellular Component	Protein Phosphatase Type 2A Complex Chromosome, Centromeric Region Nucleus Cytoplasm Centrosome Cytosol Membrane Z Disc M Band	Cytosol Troponin Complex Striated Muscle Thin Filament Sarcomere Cardiac Myofibril Cardiac Troponin Complex
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Binding Protein Phosphatase Regulator Activity Kinase Binding Protein Phosphatase Activator Activity	Actin Binding Protein Binding Tropomyosin Binding Troponin C Binding Troponin I Binding
	Biological Process	Protein Dephosphorylation Signal Transduction Regulation Of Protein Autophosphorylation Positive Regulation Of Protein Dephosphorylation Regulation Of Phosphoprotein Phosphatase Activity Negative Regulation Of Lipid Kinase Activity Negative Regulation Of Protein Localization To Plasma Membrane	Muscle Contraction Regulation Of Muscle Contraction Regulation Of Heart Contraction Muscle Filament Sliding Negative Regulation Of ATPase Activity Positive Regulation Of ATPase Activity Sarcomere Organization Response To Calcium Ion Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Contraction
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion CTLA4 inhibitory signaling Platelet sensitization by LDL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Signaling by GSK3beta mutants S33 mutants of beta-catenin aren't phosphorylated S37 mutants of beta-catenin aren't phosphorylated S45 mutants of beta-catenin aren't phosphorylated T41 mutants of beta-catenin aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex RHO GTPases Activate Formins RAF activation Negative regulation of MAPK pathway PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Striated Muscle Contraction
Drugs
Diseases			Hypertrophic cardiomyopathy (HCM) Dilated cardiomyopathy (DCM)
GWAS		Deep white matter hyperintensities ( 32517579) HDL cholesterol levels ( 32203549) Nickel levels ( 26025379)	Cardiac Troponin-T levels ( 23247143) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Height ( 28552196) Neurofibrillary tangles ( 25188341)
Interacting Genes		27 interacting genes: APC AXIN2 BCL2 BEST1 C1orf21 CHEK2 CSNK1A1 CTLA4 DAPK1 DZIP1 EIF2AK2 ERICH4 GNL3 JAK2 MAPT MOS NEK1 NOS3 PPFIA1 PPP2R1A PTTG1 SGO1 SHC1 SHFL TNNT2 TP63 USHBP1	16 interacting genes: APP KDM1A MAP3K5 MLX MORF4L1 MORF4L2 MST1 NOTCH3 PPP2R5A PRKCA TNNC1 TNNI1 TNNI3 TNNT1 TPM1 TRIM69
Entrez ID		5525	7139
HPRD ID		03384	01844
Ensembl ID		ENSG00000066027	ENSG00000118194
Uniprot IDs		Q15172	A0A0A0MRJ5 P45379 Q15607
PDB IDs		6NTS	1J1D 1J1E 4Y99 6KN7 6KN8
Enriched GO Terms of Interacting Partners?
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