PPP2R1A and PPP2R5B

Data Source:
BioGRID (two hybrid)

		PPP2R1A	PPP2R5B
Description		protein phosphatase 2 scaffold subunit Aalpha	protein phosphatase 2 regulatory subunit B'beta
Image			No pdb structure
GO Annotations	Cellular Component	Protein Phosphatase Type 2A Complex Chromosome, Centromeric Region Nucleus Cytoplasm Mitochondrion Cytosol Protein Serine/threonine Phosphatase Complex Microtubule Cytoskeleton Membrane Lateral Plasma Membrane Dendrite Extracellular Exosome	Protein Phosphatase Type 2A Complex Nucleus Cytoplasm Cytosol
	Molecular Function	Protein Serine/threonine Phosphatase Activity Protein Binding Protein Phosphatase Regulator Activity Protein Heterodimerization Activity Protein Antigen Binding	Protein Binding Protein Phosphatase Regulator Activity Protein Phosphatase Activator Activity
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Inactivation Of MAPK Activity Regulation Of DNA Replication Regulation Of Transcription, DNA-templated Protein Dephosphorylation Ceramide Metabolic Process Apoptotic Process Chromosome Segregation Mitotic Nuclear Envelope Reassembly RNA Splicing Response To Organic Substance Regulation Of G2/M Transition Of Mitotic Cell Cycle Second-messenger-mediated Signaling Regulation Of Wnt Signaling Pathway Regulation Of Cell Adhesion Negative Regulation Of Cell Growth Regulation Of Growth Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of Phosphoprotein Phosphatase Activity Regulation Of Cell Differentiation Protein-containing Complex Assembly Ciliary Basal Body-plasma Membrane Docking	Protein Dephosphorylation Regulation Of Signaling Receptor Activity Positive Regulation Of Neuron Projection Development Regulation Of Phosphatidylinositol 3-kinase Signaling Positive Regulation Of Protein-containing Complex Assembly Regulation Of Protein Autophosphorylation IRE1-mediated Unfolded Protein Response Regulation Of Phosphoprotein Phosphatase Activity Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Protein Kinase B Signaling Negative Regulation Of G0 To G1 Transition Positive Regulation Of Cell Cycle Arrest Cellular Response To Growth Factor Stimulus
Pathways		Inhibition of replication initiation of damaged DNA by RB1/E2F1 Spry regulation of FGF signaling Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Integration of energy metabolism PP2A-mediated dephosphorylation of key metabolic factors DARPP-32 events Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade ERK/MAPK targets ERKs are inactivated MASTL Facilitates Mitotic Progression Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition Initiation of Nuclear Envelope (NE) Reformation Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes CTLA4 inhibitory signaling Platelet sensitization by LDL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Signaling by GSK3beta mutants S33 mutants of beta-catenin aren't phosphorylated S37 mutants of beta-catenin aren't phosphorylated S45 mutants of beta-catenin aren't phosphorylated T41 mutants of beta-catenin aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins RAF activation Negative regulation of MAPK pathway Regulation of TP53 Degradation PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Mitotic Prometaphase Cyclin D associated events in G1 Cyclin A/B1/B2 associated events during G2/M transition AURKA Activation by TPX2 Regulation of glycolysis by fructose 2,6-bisphosphate metabolism EML4 and NUDC in mitotic spindle formation Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion XBP1(S) activates chaperone genes CTLA4 inhibitory signaling Platelet sensitization by LDL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Signaling by GSK3beta mutants S33 mutants of beta-catenin aren't phosphorylated S37 mutants of beta-catenin aren't phosphorylated S45 mutants of beta-catenin aren't phosphorylated T41 mutants of beta-catenin aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex RHO GTPases Activate Formins RAF activation Negative regulation of MAPK pathway PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs		2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid (2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acid
Diseases
GWAS			Serum uric acid levels ( 32514006)
Interacting Genes		57 interacting genes: AIMP2 AKT1 AMOTL2 ARIH2 CARD11 CARHSP1 CDC42 CDK1 CSDC2 CSNK2B DAPK1 DELEC1 DUX4 EEF2 ESR1 FBXO43 GNA12 GOLGA6A GOLGA8F GRIN1 GRIN2D HSF2 HSPD1 IPO9 LINC01554 MAP3K7 MAPK6 MCM3 PARK7 PLAAT3 PPP2CA PPP2R2A PPP2R3B PPP2R5A PPP2R5B PPP2R5D PPP4C PPP5C PRDX1 PRDX2 PTPA RAB11A RAB18 RAB7A RAP1A RORC SGO1 SGO2 SLC6A2 SMAD2 SMAD3 STRN STRN3 SUMO2 TAB1 TRADD ZFYVE9	7 interacting genes: AXIN1 CHEK2 IER3 MAPK1 PPP2CA PPP2R1A SGO1
Entrez ID		5518	5526
HPRD ID		16184	09038
Ensembl ID		ENSG00000105568	ENSG00000068971
Uniprot IDs		A8K7B7 P30153	A0A024R593 Q15173
PDB IDs		1B3U 2IE3 2IE4 2NPP 2NYL 2NYM 2PKG 3C5W 3DW8 3K7V 3K7W 4I5L 4I5N 4LAC 5W0W 6IUR 6NTS
Enriched GO Terms of Interacting Partners?
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