PPP2R1A and GRIN2D

Data Source:
HPRD (in vivo)

		PPP2R1A	GRIN2D
Description		protein phosphatase 2 scaffold subunit Aalpha	glutamate ionotropic receptor NMDA type subunit 2D
Image			No pdb structure
GO Annotations	Cellular Component	Protein Phosphatase Type 2A Complex Chromosome, Centromeric Region Nucleus Cytoplasm Mitochondrion Cytosol Protein Serine/threonine Phosphatase Complex Microtubule Cytoskeleton Membrane Lateral Plasma Membrane Dendrite Extracellular Exosome	Plasma Membrane Integral Component Of Plasma Membrane NMDA Selective Glutamate Receptor Complex Postsynaptic Density Membrane
	Molecular Function	Protein Serine/threonine Phosphatase Activity Protein Binding Protein Phosphatase Regulator Activity Protein Heterodimerization Activity Protein Antigen Binding	Ionotropic Glutamate Receptor Activity NMDA Glutamate Receptor Activity Protein Binding Ligand-gated Ion Channel Activity Glutamate-gated Calcium Ion Channel Activity Signaling Receptor Activity
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Inactivation Of MAPK Activity Regulation Of DNA Replication Regulation Of Transcription, DNA-templated Protein Dephosphorylation Ceramide Metabolic Process Apoptotic Process Chromosome Segregation Mitotic Nuclear Envelope Reassembly RNA Splicing Response To Organic Substance Regulation Of G2/M Transition Of Mitotic Cell Cycle Second-messenger-mediated Signaling Regulation Of Wnt Signaling Pathway Regulation Of Cell Adhesion Negative Regulation Of Cell Growth Regulation Of Growth Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of Phosphoprotein Phosphatase Activity Regulation Of Cell Differentiation Protein-containing Complex Assembly Ciliary Basal Body-plasma Membrane Docking	Startle Response Brain Development Adult Locomotory Behavior Calcium-mediated Signaling Ionotropic Glutamate Receptor Signaling Pathway Regulation Of Synaptic Plasticity Regulation Of Sensory Perception Of Pain Excitatory Postsynaptic Potential Long-term Synaptic Potentiation Calcium Ion Transmembrane Import Into Cytosol Excitatory Chemical Synaptic Transmission
Pathways		Inhibition of replication initiation of damaged DNA by RB1/E2F1 Spry regulation of FGF signaling Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Integration of energy metabolism PP2A-mediated dephosphorylation of key metabolic factors DARPP-32 events Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade ERK/MAPK targets ERKs are inactivated MASTL Facilitates Mitotic Progression Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition Initiation of Nuclear Envelope (NE) Reformation Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes CTLA4 inhibitory signaling Platelet sensitization by LDL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Signaling by GSK3beta mutants S33 mutants of beta-catenin aren't phosphorylated S37 mutants of beta-catenin aren't phosphorylated S45 mutants of beta-catenin aren't phosphorylated T41 mutants of beta-catenin aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins RAF activation Negative regulation of MAPK pathway Regulation of TP53 Degradation PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Mitotic Prometaphase Cyclin D associated events in G1 Cyclin A/B1/B2 associated events during G2/M transition AURKA Activation by TPX2 Regulation of glycolysis by fructose 2,6-bisphosphate metabolism EML4 and NUDC in mitotic spindle formation Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor RAF/MAP kinase cascade Neurexins and neuroligins Synaptic adhesion-like molecules Assembly and cell surface presentation of NMDA receptors Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation
Drugs		2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid (2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acid	Glutamic acid Tramadol Enflurane Atomoxetine Pentobarbital Methadone Secobarbital Meperidine Acamprosate Donepezil Guaifenesin Memantine Orphenadrine Phenobarbital Aripiprazole Tenocyclidine Prasterone Milnacipran Acetylcysteine Ketobemidone Gavestinel Magnesium acetate tetrahydrate Magnesium carbonate Esketamine Fluciclovine (18F)
Diseases
GWAS
Interacting Genes		57 interacting genes: AIMP2 AKT1 AMOTL2 ARIH2 CARD11 CARHSP1 CDC42 CDK1 CSDC2 CSNK2B DAPK1 DELEC1 DUX4 EEF2 ESR1 FBXO43 GNA12 GOLGA6A GOLGA8F GRIN1 GRIN2D HSF2 HSPD1 IPO9 LINC01554 MAP3K7 MAPK6 MCM3 PARK7 PLAAT3 PPP2CA PPP2R2A PPP2R3B PPP2R5A PPP2R5B PPP2R5D PPP4C PPP5C PRDX1 PRDX2 PTPA RAB11A RAB18 RAB7A RAP1A RORC SGO1 SGO2 SLC6A2 SMAD2 SMAD3 STRN STRN3 SUMO2 TAB1 TRADD ZFYVE9	33 interacting genes: ABL1 CDH2 CIT CLTC CTNNB1 DLG2 DLG4 DLGAP4 DNM1 DUSP4 FUS GRIN1 HNRNPU HRAS HSPA1A IL16 INA MAP2 MAP2K2 NANOS1 NF1 PATJ PPP2R1A PPP2R2A PRKCB PRKCE PRKCG RAP2A RPS6KA3 SPTAN1 SYNGAP1 TJP1 TRAF3
Entrez ID		5518	2906
HPRD ID		16184	04095
Ensembl ID		ENSG00000105568	ENSG00000105464
Uniprot IDs		A8K7B7 P30153	O15399 Q59G17
PDB IDs		1B3U 2IE3 2IE4 2NPP 2NYL 2NYM 2PKG 3C5W 3DW8 3K7V 3K7W 4I5L 4I5N 4LAC 5W0W 6IUR 6NTS
Enriched GO Terms of Interacting Partners?
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