PPP2R5B and IER3

Data Source:
HPRD (in vitro)

		PPP2R5B	IER3
Description		protein phosphatase 2 regulatory subunit B'beta	immediate early response 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Protein Phosphatase Type 2A Complex Nucleus Cytoplasm Cytosol	Nucleus Cytosol Integral Component Of Membrane
	Molecular Function	Protein Binding Protein Phosphatase Regulator Activity Protein Phosphatase Activator Activity	Protein Binding
	Biological Process	Protein Dephosphorylation Regulation Of Signaling Receptor Activity Positive Regulation Of Neuron Projection Development Regulation Of Phosphatidylinositol 3-kinase Signaling Positive Regulation Of Protein-containing Complex Assembly Regulation Of Protein Autophosphorylation IRE1-mediated Unfolded Protein Response Regulation Of Phosphoprotein Phosphatase Activity Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Protein Kinase B Signaling Negative Regulation Of G0 To G1 Transition Positive Regulation Of Cell Cycle Arrest Cellular Response To Growth Factor Stimulus	Apoptotic Process Anatomical Structure Morphogenesis Regulation Of Phosphatidylinositol 3-kinase Signaling Negative Regulation Of Apoptotic Process Regulation Of Response To DNA Damage Stimulus
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion XBP1(S) activates chaperone genes CTLA4 inhibitory signaling Platelet sensitization by LDL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Signaling by GSK3beta mutants S33 mutants of beta-catenin aren't phosphorylated S37 mutants of beta-catenin aren't phosphorylated S45 mutants of beta-catenin aren't phosphorylated T41 mutants of beta-catenin aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex RHO GTPases Activate Formins RAF activation Negative regulation of MAPK pathway PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Drugs
Diseases
GWAS		Serum uric acid levels ( 32514006)	Age-related macular degeneration ( 23455636) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Chronic obstructive pulmonary disease ( 30804561) Decreased fine motor function in Charcot-Marie-Tooth disease 1A (eating with utensils) ( 30958311) Rosacea symptom severity ( 29771307) Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome) ( 26651848) Sleep duration ( 25469926) Small cell lung carcinoma ( 28604730) Type 1 diabetes and autoimmune thyroid diseases ( 25936594) Ulcerative colitis ( 20848476)
Interacting Genes		7 interacting genes: AXIN1 CHEK2 IER3 MAPK1 PPP2CA PPP2R1A SGO1	17 interacting genes: APP AQP2 CD79A CISD2 FHL2 FKBP7 GLP1R MAPK1 MAPK3 MDM2 PPP2R5B PPP2R5C PRNP SGTA SLC13A4 TMBIM6 TMX2
Entrez ID		5526	8870
HPRD ID		09038	04295
Ensembl ID		ENSG00000068971	ENSG00000137331
Uniprot IDs		A0A024R593 Q15173	A0A1U9X7X2 P46695
PDB IDs
Enriched GO Terms of Interacting Partners?
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