CDC37 and TBK1

Data Source:
HPRD (in vitro)

		CDC37	TBK1
Description		cell division cycle 37, HSP90 cochaperone	TANK binding kinase 1
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GO Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Exosome Chaperone Complex HSP90-CDC37 Chaperone Complex	Nucleoplasm Cytoplasm Cytosol Endosome Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding Protein Kinase Regulator Activity Kinase Binding Protein Kinase Binding Heat Shock Protein Binding Unfolded Protein Binding Chaperone Binding Hsp90 Protein Binding Scaffold Protein Binding	Nucleic Acid Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Phosphatase Binding Identical Protein Binding Phosphoprotein Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Folding Protein Targeting Posttranscriptional Regulation Of Gene Expression ERBB2 Signaling Pathway Protein Stabilization Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway Positive Regulation Of Mitophagy In Response To Mitochondrial Depolarization	Activation Of Innate Immune Response Protein Phosphorylation Inflammatory Response I-kappaB Kinase/NF-kappaB Signaling Response To Virus Viral Process Positive Regulation Of Macroautophagy Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Regulation Of Type I Interferon Production Negative Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Type I Interferon Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Peptidyl-serine Phosphorylation TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Dendritic Cell Proliferation Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II Defense Response To Gram-positive Bacterium Defense Response To Virus Positive Regulation Of Type I Interferon-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Regulation Of Neuron Death Positive Regulation Of Xenophagy
Pathways		Signaling by ERBB2 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants Constitutive Signaling by EGFRvIII Regulation of necroptotic cell death Downregulation of ERBB2 signaling RHOBTB2 GTPase cycle Constitutive Signaling by Overexpressed ERBB2 Drug-mediated inhibition of ERBB2 signaling Signaling by ERBB2 KD Mutants Resistance of ERBB2 KD mutants to trastuzumab Resistance of ERBB2 KD mutants to sapitinib Resistance of ERBB2 KD mutants to tesevatinib Resistance of ERBB2 KD mutants to neratinib Resistance of ERBB2 KD mutants to osimertinib Resistance of ERBB2 KD mutants to afatinib Resistance of ERBB2 KD mutants to AEE788 Resistance of ERBB2 KD mutants to lapatinib Signaling by ERBB2 ECD mutants Signaling by ERBB2 TMD/JMD mutants Drug resistance in ERBB2 TMD/JMD mutants	IRF3 mediated activation of type 1 IFN IRF3 mediated activation of type 1 IFN Regulation of innate immune responses to cytosolic DNA STAT6-mediated induction of chemokines IRF3-mediated induction of type I IFN Interleukin-37 signaling TICAM1-dependent activation of IRF3/IRF7 TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation Negative regulators of DDX58/IFIH1 signaling Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon Potential therapeutics for SARS
Drugs			Fostamatinib
Diseases
GWAS		Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Multiple sclerosis ( 21833088) White blood cell count ( 32888494)	Amyotrophic lateral sclerosis ( 29566793 27455348) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Lung adenocarcinoma ( 28604730) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		178 interacting genes: A2M ACTB ACTG1 AKT1 AMOTL2 APOE APP AR BEND7 BHLHB9 BLZF1 BTBD10 BTBD3 C19orf44 CAMK2A CAMK2B CAMK2G CARD10 CARD9 CAVIN1 CBY2 CC2D1A CCDC138 CCDC152 CCDC91 CCHCR1 CDC37L1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CEP55 CEP70 CGGBP1 CHGA CHUK CKS1B CKS2 CRYM CSNK2A1 CSNK2A2 CT45A1 CTAG1A CTAG1B CUTC CYP2C9 DCTN1 DEAF1 DISC1 ECSIT EIF2AK1 EIF2S1 ELAVL3 ENOX2 EXOSC1 FAM118A FAM9B FATE1 FBXL12 FBXW4 GAS7 GAS8 GCDH GCH1 GFAP GMCL1 GOLGA2 GOLGA6L9 GRAMD2B GRIPAP1 HIVEP1 HOMER3 HSF2BP HSP90AA1 IFIT5 IKBKB IKBKE IKBKG IKZF3 IMMT JRK KATNBL1 KCTD13 KCTD9 KIFC3 KLHL2 KRT75 KRT76 LMNB2 LONP1 LOXL4 LUC7L2 LZTS1 MAD1L1 MAP3K14 MAP3K3 MDFI MID1 MIPOL1 MRPL9 MTOR MZT2B NCOA5 NECAB1 NECAB2 NOS3 NR2C2 NRIP3 NT5C1A OGA PAICS PDE9A PIBF1 PNMA2 POU6F2 PPHLN1 PPP5C PRAM1 PRDX2 PRKAR1B PRMT1 PRMT5 PRPH PRR20A PRR20B PRR20C PRR20D PRR20E PSMC6 PSME1 PTGES3 RABGEF1 RAD23A RAF1 REEP6 RNF32 ROPN1 RPS15A SAFB SEPTIN3 SNX5 SPTBN4 SQSTM1 SRC SRRM4 SSNA1 STAMBPL1 STIP1 STK11 STK32A STX1A SYCE2 SYCP3 TBK1 TCF4 THAP1 THAP7 TNFAIP1 TNIP1 TRAF2 TRAF3 TRAF5 TRIM54 UBE2I USHBP1 WAC ZBED1 ZBTB26 ZBTB8A ZNF205 ZNF235 ZNF266 ZNF276 ZNF655 ZNF667 ZNF837	44 interacting genes: AGO2 APP ATG9A AZI2 CALCOCO2 CDC37 CDC42BPG CYLD HSP90AA1 HSP90AB1 IKBKB IKBKG IRF3 IRF5 IRF7 MAP1LC3B MAVS MBP MIB2 MTPAP NCK1 NEDD4 NFKBIA PROS1 PTPRD RELA RIPK1 RNF128 RPS6KB1 SIKE1 SMCR8 SMURF1 SQSTM1 STX11 TANK TICAM1 TRAF2 TRAF3 TRAF3IP2 TRAF5 TRIM21 TRIM27 TXLNG XIAP
Entrez ID		11140	29110
HPRD ID		05456	05322
Ensembl ID		ENSG00000105401	ENSG00000183735
Uniprot IDs		A0A024R7B7 Q16543	Q9UHD2
PDB IDs		1US7 2K5B 2N5X 2NCA 2W0G 5FWK 5FWL 5FWM 5FWP 5HPE	4EFO 4EUT 4EUU 4IM0 4IM2 4IM3 4IW0 4IWO 4IWP 4IWQ 5EOA 5EOF 5EP6 5W5V 6BNY 6BOD 6BOE 6CQ0 6CQ4 6CQ5 6NT9 6O8B 6RSR 6RST 6RSU
Enriched GO Terms of Interacting Partners?
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