ARHGAP17 and PACSIN1

Data Source:
HPRD (in vitro)

		ARHGAP17	PACSIN1
Description		Rho GTPase activating protein 17	protein kinase C and casein kinase substrate in neurons 1
Image		No pdb structure
GO Annotations	Cellular Component	Intracellular Anatomical Structure Nucleoplasm Cytosol Plasma Membrane Bicellular Tight Junction	Cytoplasm Endosome Cytosol Cytoskeleton Plasma Membrane COPI-coated Vesicle Cytoplasmic Vesicle Membrane Ruffle Membrane Axon Terminus Synapse Perinuclear Region Of Cytoplasm Photoreceptor Ribbon Synapse Presynaptic Endocytic Zone
	Molecular Function	GTPase Activator Activity Protein Binding SH3 Domain Binding	Protein Binding Phospholipid Binding Identical Protein Binding
	Biological Process	Actin Filament Organization Signal Transduction Calcium-ion Regulated Exocytosis Regulation Of Actin Cytoskeleton Organization Regulation Of Rac Protein Signal Transduction Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction	Cytoskeleton Organization Actin Filament Organization Regulation Of Endocytosis Negative Regulation Of Endocytosis Synaptic Vesicle Endocytosis Neuron Projection Morphogenesis Protein Localization To Membrane Protein Localization To Plasma Membrane Plasma Membrane Tubulation Positive Regulation Of Dendrite Development
Pathways		Rho GTPase cycle	Clathrin-mediated endocytosis
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223)	Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body mass index ( 29273807 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Electrocardiographic traits ( 32602732) Free thyroxine concentration ( 30367059) High density lipoprotein cholesterol levels ( 30498476) Inflammatory bowel disease ( 27569725) Refractive error ( 32231278) Waist-to-hip ratio adjusted for BMI ( 28552196)
Interacting Genes		16 interacting genes: ABL1 APP BTK CDC42 CRK CTTN DNMBP FNBP1 GRB2 LCK PACSIN1 PIK3R1 RAC1 SH3GLB1 SRC TRIP10	25 interacting genes: ANKRD24 ARHGAP17 DNM1 EHBP1 FTH1 GAS7 HTT ITCH JADE2 KAT7 KHDRBS1 MAPT MT-ATP8 PACSIN2 PACSIN3 PLEKHF2 POT1 RTKN2 SOS1 SPTBN1 SYNJ1 TPM4 TRPV4 WASF2 WASL
Entrez ID		55114	29993
HPRD ID		12207	05936
Ensembl ID		ENSG00000140750	ENSG00000124507
Uniprot IDs		Q68EM7	Q5TZC3 Q9BY11
PDB IDs			3HAH 3HAI 3Q84 3QNI
Enriched GO Terms of Interacting Partners?
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