PPP1R7 and SPRED1

Data Source:
BioGRID (two hybrid)

		PPP1R7	SPRED1
Description		protein phosphatase 1 regulatory subunit 7	sprouty related EVH1 domain containing 1
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GO Annotations	Cellular Component	Nucleus Chromosome Cytoplasm Extracellular Exosome	Nucleoplasm Cytosol Plasma Membrane Caveola Cytoplasmic Vesicle
	Molecular Function	Protein Binding Protein Phosphatase Regulator Activity Enzyme Regulator Activity	Stem Cell Factor Receptor Binding Protein Binding Protein Kinase Binding Phosphatase Binding Protein Serine/threonine Kinase Inhibitor Activity
	Biological Process	Positive Regulation Of Protein Dephosphorylation Regulation Of Phosphoprotein Phosphatase Activity	MAPK Cascade Inactivation Of MAPK Activity Negative Regulation Of Protein Kinase Activity Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Peptidyl-threonine Phosphorylation Negative Regulation Of Phosphatase Activity Negative Regulation Of Angiogenesis Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of MAPK Cascade Negative Regulation Of MAPK Cascade Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Vasculogenesis Involved In Coronary Vascular Morphogenesis Negative Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Regulation Of Protein Deacetylation Negative Regulation Of Lens Fiber Cell Differentiation
Pathways			Regulation of RAS by GAPs FGFRL1 modulation of FGFR1 signaling RAS signaling downstream of NF1 loss-of-function variants
Drugs
Diseases			Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
GWAS			Bipolar disorder ( 20351715) Birth weight ( 31043758) Cognitive performance (processing speed) ( 31598132) Crohn's disease ( 23128233) Erosive tooth wear (severe vs non-severe) ( 29898447) Erosive tooth wear (severe vs none or mild) ( 29898447) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) Hypersomnia (HLA-DQB1*06:02 negative) ( 23646285)
Interacting Genes		12 interacting genes: CLNK FER HGS MAPK6 MYH3 PPP1CA PPP1CB PPP1CC SPRED1 TAB1 TNFRSF6B USHBP1	37 interacting genes: ANKS1A AQP1 BEX2 BLZF1 C2orf68 CCDC185 CDKN1A CREB5 DNAJB11 FAM118B FAM90A1 GLYCTK HEXIM2 HPCAL4 HSF2BP IL16 KIT MAB21L3 MEOX2 NAGK NCALD OSGEP PIH1D2 PPP1CA PPP1R7 PRPF18 RCC1 RIN1 SPG21 SUV39H1 TSC22D1 TTC19 VSNL1 ZNF408 ZNF417 ZNF587 ZNF655
Entrez ID		5510	161742
HPRD ID		04192	11601
Ensembl ID		ENSG00000115685	ENSG00000166068
Uniprot IDs		A0A140VK83 Q15435	Q7Z699
PDB IDs		6HKW 6MKY 6OBN 6OBP	3SYX 6V65 6V6F
Enriched GO Terms of Interacting Partners?
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