PPP1R7 and FER

Data Source:
BioGRID (two hybrid)

		PPP1R7	FER
Description		protein phosphatase 1 regulatory subunit 7	FER tyrosine kinase
Image
GO Annotations	Cellular Component	Nucleus Chromosome Cytoplasm Extracellular Exosome	Chromatin Nucleus Cytoplasm Cytosol Cell Cortex Actin Cytoskeleton Microtubule Cytoskeleton Lamellipodium Cell Junction Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
	Molecular Function	Protein Binding Protein Phosphatase Regulator Activity Enzyme Regulator Activity	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signaling Receptor Binding Epidermal Growth Factor Receptor Binding Protein Binding ATP Binding Protein Phosphatase 1 Binding Lipid Binding
	Biological Process	Positive Regulation Of Protein Dephosphorylation Regulation Of Phosphoprotein Phosphatase Activity	Microtubule Cytoskeleton Organization Regulation Of Protein Phosphorylation Protein Phosphorylation Chemotaxis Cell Adhesion Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Tyrosine Phosphorylation Of STAT Protein Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Regulation Of Lamellipodium Assembly Regulation Of Fibroblast Migration Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway Cell Differentiation Positive Regulation Of Cell Migration Positive Regulation Of Actin Filament Polymerization Actin Cytoskeleton Reorganization Response To Lipopolysaccharide Cellular Response To Insulin Stimulus Negative Regulation Of Mast Cell Activation Involved In Immune Response Substrate Adhesion-dependent Cell Spreading Cellular Response To Reactive Oxygen Species Extracellular Matrix-cell Signaling Intracellular Signal Transduction Cellular Response To Macrophage Colony-stimulating Factor Stimulus Response To Platelet-derived Growth Factor Insulin Receptor Signaling Pathway Via Phosphatidylinositol 3-kinase Fc-epsilon Receptor Signaling Pathway Kit Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Mast Cell Degranulation Cell-cell Adhesion Mediated By Cadherin Innate Immune Response Protein Autophosphorylation Platelet-derived Growth Factor Receptor Signaling Pathway Diapedesis Positive Regulation Of NF-kappaB Transcription Factor Activity Interleukin-6-mediated Signaling Pathway
Pathways			Signaling by SCF-KIT
Drugs			Fostamatinib
Diseases
GWAS			Adiponectin levels ( 21700879) Asthma ( 27611488) Asthma (childhood onset) ( 27611488) Early-onset Parkinson's disease ( 28256260) Height ( 20881960 25282103) Intraocular pressure ( 29617998 29785010 31959993 30054594 29235454) Paneth cell defects in Crohn's disease ( 28352666) PR interval ( 32439900) Pulse pressure ( 27841878 30578418) Sepsis from pneumonia (survival) ( 25533491) Systolic blood pressure ( 27841878 30578418) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412) White blood cell count ( 32888494)
Interacting Genes		12 interacting genes: CLNK FER HGS MAPK6 MYH3 PPP1CA PPP1CB PPP1CC SPRED1 TAB1 TNFRSF6B USHBP1	19 interacting genes: CALM1 CDH1 CRK CTNNB1 CTNND1 CTTN EGFR ERBB2 ERBB3 IRS1 JAK1 JUP KCTD4 PIK3R1 PIK3R3 PPP1R7 STAT3 TMF1 YWHAB
Entrez ID		5510	2241
HPRD ID		04192	01491
Ensembl ID		ENSG00000115685	ENSG00000151422
Uniprot IDs		A0A140VK83 Q15435	P16591 Q6PEJ9 W0S0X4 W0S1B5
PDB IDs		6HKW 6MKY 6OBN 6OBP	2KK6 6KC4
Enriched GO Terms of Interacting Partners?
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