SPRED1 and PPP1R7

Data Source:
BioGRID (two hybrid)

		SPRED1	PPP1R7
Description		sprouty related EVH1 domain containing 1	protein phosphatase 1 regulatory subunit 7
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GO Annotations	Cellular Component	Nucleoplasm Cytosol Plasma Membrane Caveola Cytoplasmic Vesicle	Nucleus Chromosome Cytoplasm Extracellular Exosome
	Molecular Function	Stem Cell Factor Receptor Binding Protein Binding Protein Kinase Binding Phosphatase Binding Protein Serine/threonine Kinase Inhibitor Activity	Protein Binding Protein Phosphatase Regulator Activity Enzyme Regulator Activity
	Biological Process	MAPK Cascade Inactivation Of MAPK Activity Negative Regulation Of Protein Kinase Activity Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Peptidyl-threonine Phosphorylation Negative Regulation Of Phosphatase Activity Negative Regulation Of Angiogenesis Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of MAPK Cascade Negative Regulation Of MAPK Cascade Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Vasculogenesis Involved In Coronary Vascular Morphogenesis Negative Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Regulation Of Protein Deacetylation Negative Regulation Of Lens Fiber Cell Differentiation	Positive Regulation Of Protein Dephosphorylation Regulation Of Phosphoprotein Phosphatase Activity
Pathways		Regulation of RAS by GAPs FGFRL1 modulation of FGFR1 signaling RAS signaling downstream of NF1 loss-of-function variants
Drugs
Diseases		Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
GWAS		Bipolar disorder ( 20351715) Birth weight ( 31043758) Cognitive performance (processing speed) ( 31598132) Crohn's disease ( 23128233) Erosive tooth wear (severe vs non-severe) ( 29898447) Erosive tooth wear (severe vs none or mild) ( 29898447) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) Hypersomnia (HLA-DQB1*06:02 negative) ( 23646285)
Interacting Genes		37 interacting genes: ANKS1A AQP1 BEX2 BLZF1 C2orf68 CCDC185 CDKN1A CREB5 DNAJB11 FAM118B FAM90A1 GLYCTK HEXIM2 HPCAL4 HSF2BP IL16 KIT MAB21L3 MEOX2 NAGK NCALD OSGEP PIH1D2 PPP1CA PPP1R7 PRPF18 RCC1 RIN1 SPG21 SUV39H1 TSC22D1 TTC19 VSNL1 ZNF408 ZNF417 ZNF587 ZNF655	12 interacting genes: CLNK FER HGS MAPK6 MYH3 PPP1CA PPP1CB PPP1CC SPRED1 TAB1 TNFRSF6B USHBP1
Entrez ID		161742	5510
HPRD ID		11601	04192
Ensembl ID		ENSG00000166068	ENSG00000115685
Uniprot IDs		Q7Z699	A0A140VK83 Q15435
PDB IDs		3SYX 6V65 6V6F	6HKW 6MKY 6OBN 6OBP
Enriched GO Terms of Interacting Partners?
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