MED9 and CBX4

Data Source:
HPRD (in vitro)

		MED9	CBX4
Description		mediator complex subunit 9	chromobox 4
Image		No pdb structure
GO Annotations	Cellular Component	Mediator Complex	Nucleus Nucleoplasm Nuclear Body Nuclear Speck PcG Protein Complex PRC1 Complex
	Molecular Function	Transcription Coregulator Activity Protein Binding	Transcription Regulatory Region Sequence-specific DNA Binding Chromatin Binding Transcription Corepressor Activity Single-stranded RNA Binding Protein Binding SUMO Transferase Activity Enzyme Binding SUMO Binding Methylated Histone Binding Phosphoprotein Binding SUMO Ligase Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Protein Sumoylation Negative Regulation Of Apoptotic Process Negative Regulation Of Transcription, DNA-templated
Pathways		PPARA activates gene expression Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation	Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription
Drugs
Diseases
GWAS		Birth weight ( 31043758) Estimated glomerular filtration rate ( 31152163)	Brain morphology (MOSTest) ( 32665545) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Glucocorticoid-induced osteonecrosis (age 10 years and older) ( 26265699) Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels) ( 24528284)
Interacting Genes		26 interacting genes: APP CBX4 CDK8 MED1 MED11 MED12 MED13 MED14 MED16 MED18 MED19 MED22 MED23 MED24 MED25 MED26 MED27 MED28 MED29 MED30 MED31 MED4 MED6 MED7 MED8 USP47	23 interacting genes: ARID3C CBS CREBBP CSNK2B CTBP1 CTBP2 FHL1 H3-4 KMT2A LNX2 MBD1 MED9 MX1 RB1 RING1 RNF2 SATB1 SKIL SPOP SUV39H1 TRIM21 UBE2I ZEB2
Entrez ID		55090	8535
HPRD ID		14383	04357
Ensembl ID		ENSG00000141026	ENSG00000141582
Uniprot IDs		Q9NWA0	A0A0S2Z5B2 O00257
PDB IDs			2K28 3I8Z 5EPL
Enriched GO Terms of Interacting Partners?
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