CBX4 and ARID3C

Data Source:
BioGRID (two hybrid)

		CBX4	ARID3C
Description		chromobox 4	AT-rich interaction domain 3C
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Body Nuclear Speck PcG Protein Complex PRC1 Complex	Nucleus Cytoplasm Membrane Raft
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding Chromatin Binding Transcription Corepressor Activity Single-stranded RNA Binding Protein Binding SUMO Transferase Activity Enzyme Binding SUMO Binding Methylated Histone Binding Phosphoprotein Binding SUMO Ligase Activity	DNA Binding Chromatin Binding Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Protein Sumoylation Negative Regulation Of Apoptotic Process Negative Regulation Of Transcription, DNA-templated	Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Glucocorticoid-induced osteonecrosis (age 10 years and older) ( 26265699) Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels) ( 24528284)
Interacting Genes		23 interacting genes: ARID3C CBS CREBBP CSNK2B CTBP1 CTBP2 FHL1 H3-4 KMT2A LNX2 MBD1 MED9 MX1 RB1 RING1 RNF2 SATB1 SKIL SPOP SUV39H1 TRIM21 UBE2I ZEB2	3 interacting genes: C14orf119 CBX4 RNF4
Entrez ID		8535	138715
HPRD ID		04357	18550
Ensembl ID		ENSG00000141582	ENSG00000205143
Uniprot IDs		A0A0S2Z5B2 O00257	A6NKF2
PDB IDs		2K28 3I8Z 5EPL
Enriched GO Terms of Interacting Partners?
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