AUH and FAM107A

Data Source:
BioGRID (two hybrid)

		AUH	FAM107A
Description		AU RNA binding methylglutaconyl-CoA hydratase	family with sequence similarity 107 member A
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix	Stress Fiber Nucleus Cytoplasm Focal Adhesion Actin Cytoskeleton Nuclear Speck Ruffle Membrane Neuron Projection Synapse
	Molecular Function	MRNA 3'-UTR Binding Enoyl-CoA Hydratase Activity Methylglutaconyl-CoA Hydratase Activity Itaconyl-CoA Hydratase Activity	Molecular_function Actin Binding Protein Binding
	Biological Process	Leucine Catabolic Process Fatty Acid Beta-oxidation Branched-chain Amino Acid Catabolic Process	Regulation Of Cell Growth Cell Cycle Actin Filament Polymerization Positive Regulation Of Cell Migration Positive Regulation Of Protein Ubiquitination Regulation Of Protein Stability Cellular Response To Nutrient Levels Regulation Of Actin Cytoskeleton Organization Cognition Actin Filament Bundle Assembly Negative Regulation Of Focal Adhesion Assembly Regulation Of Microtubule Cytoskeleton Organization Cellular Response To Glucocorticoid Stimulus Negative Regulation Of Long-term Synaptic Potentiation Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Branched-chain amino acid catabolism
Drugs
Diseases		3-Methylglutaconic aciduria (MGCA)
GWAS		Bipolar disorder (inflammation and infection response interaction) ( 25781172) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494) HDL cholesterol levels ( 32203549) Inflammatory bowel disease ( 28067908) Response to Homoharringtonine (cytotoxicity) ( 25628645) Reticulocyte fraction of red cells ( 32888494) Sum eosinophil basophil counts ( 27863252) Total bilirubin levels ( 29403010) Type 2 diabetes nephropathy ( 21150874)	Blood protein levels ( 30072576) Night sleep phenotypes ( 27126917)
Interacting Genes		1 interacting genes: FAM107A	58 interacting genes: AGMAT APPBP2 AUH AZI2 BEGAIN BIRC8 CALCOCO2 CANX CCDC125 CCDC136 CCDC57 CCDC85B CPSF3 DAPK1 EFEMP2 EFHC2 EIF4A1 ESRRG FKBP6 FSD2 GFM2 GOLGA6L9 HFM1 HOOK2 HSF2BP HSPA14 HSPD1 HTRA1 IQUB ITPRID2 KRT15 KRT19 KRT27 KRT40 KRTAP4-12 LDOC1 LZTS2 MEIOB MID2 MTREX MTUS2 NEXN NFKBID NINL PLSCR1 PNMA1 POMP PSMD6 RAB18 RINT1 RNLS SPATA22 TADA2A TRAF2 TRIM37 USHBP1 VIM WDR47
Entrez ID		549	11170
HPRD ID		08987	09753
Ensembl ID		ENSG00000148090	ENSG00000168309
Uniprot IDs		B4DYI6 Q13825	A0A024R327 O95990 Q6IAM1
PDB IDs		1HZD 2ZQQ 2ZQR
Enriched GO Terms of Interacting Partners?
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