TET2 and DCAF1

Data Source:
BioGRID (pull down)

		TET2	DCAF1
Description		tet methylcytosine dioxygenase 2	DDB1 and CUL4 associated factor 1
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GO Annotations	Cellular Component	Nucleus	Fibrillar Center Nucleus Nucleoplasm Cytoplasm COP9 Signalosome Cul4-RING E3 Ubiquitin Ligase Complex
	Molecular Function	DNA Binding Protein Binding Ferrous Iron Binding Zinc Ion Binding Methylcytosine Dioxygenase Activity	Protein Binding ATP Binding Estrogen Receptor Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity Histone Kinase Activity (H2A-T120 Specific)
	Biological Process	5-methylcytosine Catabolic Process Protein O-linked Glycosylation Cell Cycle Myeloid Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Oxidative Demethylation DNA Demethylation Histone H3-K4 Trimethylation	Negative Regulation Of Transcription By RNA Polymerase II Viral Process Protein Ubiquitination B Cell Differentiation V(D)J Recombination Cell Competition In A Multicellular Organism Histone H2A-T120 Phosphorylation
Pathways		TET1,2,3 and TDG demethylate DNA	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Adventurousness ( 30643258) Apolipoprotein A1 levels ( 32203549) Birth weight ( 31043758) Blond vs. brown/black hair color ( 30531825) Breast cancer ( 29059683 23535729) Breast cancer, ovarian cancer or prostate cancer (pleiotropy) ( 27432226) Chronic obstructive pulmonary disease ( 28166215 30804561) Coffee consumption ( 31046077) Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Colorectal or endometrial cancer ( 26621817) Estimated glomerular filtration rate ( 31451708) Extremely high intelligence ( 29520040) FEV1 ( 30804560) General cognitive ability ( 29844566) General risk tolerance (MTAG) ( 30643258) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 30598549) Height ( 20881960 25429064 31562340) Household income (MTAG) ( 31844048) Immune response to anthrax vaccine ( 22658931) Intelligence (MTAG) ( 29326435) Lung function (FEV1) ( 28166213) Lung function (FEV1/FVC) ( 28166213 30804560) Lung function (low FEV1 vs high FEV1) ( 26423011) Lung function in never smokers (low FEV1 vs high FEV1) ( 26423011) Lymphocyte counts ( 29403010 27863252) Lymphocyte percentage of white cells ( 32888494 27863252) Melanoma ( 24980573) Molybdenum levels ( 26025379) Multiple sclerosis ( 31604244 24076602) Myeloproliferative neoplasms ( 33057200) Neutrophil percentage of white cells ( 32888494 27863252) Offspring birth weight ( 31043758) Peak expiratory flow ( 30804560) Platelet count ( 32888494) Plateletcrit ( 27863252) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Prostate cancer ( 25939597 19767753) Pulmonary function ( 21946350) Regular attendance at a religious group ( 29970889) Self-reported risk-taking behaviour ( 30271922) Tonsillectomy ( 27182965 28928442) Western dietary pattern ( 28644415)	Asthma ( 32296059)
Interacting Genes		19 interacting genes: DCAF1 ECD EIF2B2 HLF HOXB9 KEAP1 MED1 MNAT1 OGT PHC1 PKNOX1 RAI1 SMAD1 STAT5A TBC1D4 TFEC VPS72 ZCCHC14 ZNF207	19 interacting genes: ATM ATR CCP110 EXO1 FOXM1 H3-3A H3-4 H3C1 HLTF KATNA1 NF2 PRKDC PYGO2 RAG1 RBX1 SAMHD1 TET2 TP53 UBE2D2
Entrez ID		54790	9730
HPRD ID		07876	11674
Ensembl ID		ENSG00000168769	ENSG00000145041
Uniprot IDs		A0A024RDF7 A0A158SIU0 Q6N021	Q9Y4B6
PDB IDs		4NM6 5D9Y 5DEU	3WA0 4CC9 4P7I 4PXW 4Z8L 5AJA 5JK7 6N45
Enriched GO Terms of Interacting Partners?
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