POLA1 and HELB

Data Source:
HPRD (in vivo, in vitro)

		POLA1	HELB
Description		DNA polymerase alpha 1, catalytic subunit	DNA helicase B
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nuclear Envelope Nucleoplasm Alpha DNA Polymerase:primase Complex Nucleolus Cytosol Nuclear Matrix	Intracellular Anatomical Structure Nucleus DNA Replication Factor A Complex Nucleolus Cytoplasm Site Of Double-strand Break
	Molecular Function	Nucleotide Binding DNA Binding Chromatin Binding DNA Replication Origin Binding Single-stranded DNA Binding DNA-directed DNA Polymerase Activity Protein Binding Purine Nucleotide Binding Pyrimidine Nucleotide Binding Protein Kinase Binding Metal Ion Binding 4 Iron, 4 Sulfur Cluster Binding	RNA Binding ATP Binding Single-stranded DNA Helicase Activity 5'-3' DNA Helicase Activity Protein-containing Complex Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle DNA Synthesis Involved In DNA Repair DNA Replication DNA Replication, Synthesis Of RNA Primer DNA Replication Initiation DNA Strand Elongation Involved In DNA Replication Leading Strand Elongation Lagging Strand Elongation DNA Repair Nucleotide-excision Repair Double-strand Break Repair Via Nonhomologous End Joining Viral Process Telomere Maintenance Via Semi-conservative Replication Regulation Of Type I Interferon Production Mitotic DNA Replication Initiation DNA Synthesis Involved In UV-damage Excision Repair	Maturation Of SSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) DNA Replication DNA Replication, Synthesis Of RNA Primer DNA Repair Cellular Response To DNA Damage Stimulus DNA Duplex Unwinding Regulation Of DNA Double-strand Break Processing Negative Regulation Of Double-strand Break Repair Via Homologous Recombination
Pathways		Inhibition of replication initiation of damaged DNA by RB1/E2F1 Polymerase switching on the C-strand of the telomere Telomere C-strand synthesis initiation DNA replication initiation Activation of the pre-replicative complex Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand G1/S-Specific Transcription
Drugs		Cladribine Clofarabine Fludarabine Nelarabine
Diseases
GWAS		Mean platelet volume ( 32888494) Platelet count ( 32888494)	Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Menopause (age at onset) ( 26414677) White blood cell count (basophil) ( 29403010 27863252)
Interacting Genes		20 interacting genes: CCNA2 CCNB1 CDC45 CDK1 CDK2 CDK2AP1 GINS4 HELB PARP1 POLA2 POLE PRIM2 RAD51 RB1 RBMS1 SERPINA3 SMC1A SUMO2 TP53 XRCC5	3 interacting genes: POLA1 POLA2 RPA1
Entrez ID		5422	92797
HPRD ID		02416	09979
Ensembl ID		ENSG00000101868	ENSG00000127311
Uniprot IDs		A6NMQ1 P09884	Q8NG08
PDB IDs		1K0P 1K18 1N5G 4Q5V 4QCL 4Y97 5EXR 5IUD 6AS7
Enriched GO Terms of Interacting Partners?
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