POLA1 and RBMS1

Data Source:
HPRD (in vitro, two hybrid, in vivo)

		POLA1	RBMS1
Description		DNA polymerase alpha 1, catalytic subunit	RNA binding motif single stranded interacting protein 1
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GO Annotations	Cellular Component	Chromatin Nucleus Nuclear Envelope Nucleoplasm Alpha DNA Polymerase:primase Complex Nucleolus Cytosol Nuclear Matrix	Nucleus Cytosol Ribonucleoprotein Complex
	Molecular Function	Nucleotide Binding DNA Binding Chromatin Binding DNA Replication Origin Binding Single-stranded DNA Binding DNA-directed DNA Polymerase Activity Protein Binding Purine Nucleotide Binding Pyrimidine Nucleotide Binding Protein Kinase Binding Metal Ion Binding 4 Iron, 4 Sulfur Cluster Binding	Double-stranded DNA Binding Single-stranded DNA Binding RNA Binding MRNA 3'-UTR Binding Protein Binding Poly(A) Binding Poly(U) RNA Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle DNA Synthesis Involved In DNA Repair DNA Replication DNA Replication, Synthesis Of RNA Primer DNA Replication Initiation DNA Strand Elongation Involved In DNA Replication Leading Strand Elongation Lagging Strand Elongation DNA Repair Nucleotide-excision Repair Double-strand Break Repair Via Nonhomologous End Joining Viral Process Telomere Maintenance Via Semi-conservative Replication Regulation Of Type I Interferon Production Mitotic DNA Replication Initiation DNA Synthesis Involved In UV-damage Excision Repair	DNA Replication RNA Processing
Pathways		Inhibition of replication initiation of damaged DNA by RB1/E2F1 Polymerase switching on the C-strand of the telomere Telomere C-strand synthesis initiation DNA replication initiation Activation of the pre-replicative complex Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand G1/S-Specific Transcription
Drugs		Cladribine Clofarabine Fludarabine Nelarabine
Diseases
GWAS		Mean platelet volume ( 32888494) Platelet count ( 32888494)	Adult body size ( 32376654) Amyotrophic lateral sclerosis ( 19451621) Basal cell carcinoma ( 31174203) Body size at age 10 ( 32376654) Chronotype ( 30696823) FEV1 ( 30804560) Gut microbiota relative abundance (Ruminococcus belonging to family Lachnospiraceae) ( 33208821) HDL cholesterol levels ( 32203549) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Idiopathic membranous nephropathy ( 21323541) Intelligence (MTAG) ( 29326435) Lung function (FVC) ( 30804560) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494 27863252) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494 27863252) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Peak expiratory flow ( 30804560) Refractive error ( 32231278) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Systolic blood pressure ( 30224653) Tourette syndrome ( 30818990) Triglyceride levels ( 32203549) Type 2 diabetes ( 22885922 30054458 29358691 30297969 20418489) Weight ( 28552196 31647587) White blood cell count ( 32888494 27863252)
Interacting Genes		20 interacting genes: CCNA2 CCNB1 CDC45 CDK1 CDK2 CDK2AP1 GINS4 HELB PARP1 POLA2 POLE PRIM2 RAD51 RB1 RBMS1 SERPINA3 SMC1A SUMO2 TP53 XRCC5	9 interacting genes: MIR16-2 MIR205 MIR29A MIR7-1 MIR92A2 MIR93 MIRLET7G POLA1 TFCP2
Entrez ID		5422	5937
HPRD ID		02416	03814
Ensembl ID		ENSG00000101868	ENSG00000153250
Uniprot IDs		A6NMQ1 P09884	A0A0S2Z499 A0A0S2Z4B3 B4DN88 P29558
PDB IDs		1K0P 1K18 1N5G 4Q5V 4QCL 4Y97 5EXR 5IUD 6AS7	1X5O
Enriched GO Terms of Interacting Partners?
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