PMP22 and TSPAN12

Data Source:
BioGRID (two hybrid)

		PMP22	TSPAN12
Description		peripheral myelin protein 22	tetraspanin 12
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane Synapse	Integral Component Of Plasma Membrane Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding	Protein Binding Wnt-activated Receptor Activity
	Biological Process	Chemical Synaptic Transmission Peripheral Nervous System Development Cell Death Bleb Assembly Myelin Assembly	Angiogenesis Cell Surface Receptor Signaling Pathway Retina Layer Formation Wnt Signaling Pathway Regulation Of Angiogenesis Regulation Of Vascular Endothelial Growth Factor Signaling Pathway
Pathways		EGR2 and SOX10-mediated initiation of Schwann cell myelination
Drugs
Diseases		Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy	Familial exudative vitreoretinopathy (FEVR), including: Exudative vitreoretinopathy 1 (EVR1); Exudative vitreoretinopathy2, X-linked (EVR2); Exudative vitreoretinopathy 4 (EVR4); Exudative vitreoretinopathy 5 (EVR5); Norrie disease (ND)
GWAS		Allergic rhinitis ( 25085501) Amyotrophic lateral sclerosis ( 29566793) Corneal structure ( 23291589) Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917) Preterm birth (maternal effect) ( 28877031) Resting heart rate ( 27798624)	Bitter alcoholic beverage consumption ( 31046077) Heel bone mineral density ( 30598549)
Interacting Genes		59 interacting genes: APOL3 ARL13B ASGR2 ATP6AP2 C16orf54 CANX CD3G CD53 CD69 CEACAM3 CLDN18 CLDN5 CLDN6 CLEC12B CLEC14A CREB3 CREB3L1 DDX52 EBP EDA EMP1 ERGIC3 FAM209A FCGRT FFAR2 GJA8 GPR42 GPR61 GPRC5D IFNGR2 KCNJ6 KCNN4 KLRC1 LMNA MPZ MS4A7 OPRM1 PDZK1IP1 PEX19 PGRMC2 REEP4 SCN3B SDC4 SHISAL1 SLC18A1 SLC38A1 SMIM3 SPACA1 STOM SYT2 TLCD4 TM4SF18 TM4SF19 TMEM139 TMEM14B TMEM30B TMEM31 TMX1 TSPAN12	21 interacting genes: CDS2 CTXN3 CXCL16 CYBC1 EMP3 GPR25 GPR37L1 IGFBP5 MARCHF2 MGST3 NINJ2 PMP22 RFT1 RNF152 STX8 TEX264 TFCP2 TMEM140 TMEM147 TMEM182 TMEM218
Entrez ID		5376	23554
HPRD ID		03059	15509
Ensembl ID		ENSG00000109099	ENSG00000106025
Uniprot IDs		A8MU75 Q01453 Q6FH25	A0A024R740 O95859
PDB IDs
Enriched GO Terms of Interacting Partners?
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